The Myosin superfamily is a large and diverse protein family, and its members are grouped into many classes, are involved in a number of cellular pathways (1). Myosins contain actin- and ATP-binding sites in their conserved catalytic head domain and localize to a number of intracellular compartments and participate in many trafficking and anchoring events. A number of myosin-binding proteins have been discovered, and their identities have often provided information that is essential to the understanding of cellular functions of these motor proteins (2).
Immunohistochemistry-Paraffin: Myosin Antibody
Myosin has raised an interest because of its role in tumor progression. Increased levels of Myosin have been documented in several cancers. An immunohistochemical study performed using tissue arrays and specific antibodies against myosin revealed high expression of Myosin in colorectal cancers. Western blot analysis with anti-Myosin antibodies demonstrated increased expression of myosin (3). Anti-Myosin inhibitors were found to be effective in decreasing the invasiveness in several cancer cell lines suggesting a possible role for Myosin in control of the contractile forces (4). Tumors with high myosin expression were found to be significantly associated with higher probability of metastasis in several cancers suggesting myosin expression in cancers is associated with tumor progression.
Novus Biologicals offers a wide selection of Mysoin related reagents, including:
