WT1 Antibody (CAN-R9(IHC)-56-2)

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Wilm's Tumor (WT) is a 55 kDa protein thought to play a major role in various cancers and developmental disorders, commonly kidney tumors and glomerular diseases. WT is a zinc finger transcription factor that is mutated in Wilm's tumors and highly expressed in a wide variety of other malignancies (1). It is believed that WT in its two isoforms acts as both a transcription factor and a post-transcriptional regulator that binds RNA and can interact with splicing components (2). Mutations in the zinc finger regions of WT are detected in nearly all patients of Denys-Drash syndrome and in some patients with isolated diffuse mesangial sclerosis. Also, mutations leading to the loss of the transcription factor isoform have been observed in all patients with Frasier syndrome (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: ICC/IF, IF/IHC, IHC-P, WB.

Showing Publications 1 - 5 of 5.

Publications using NBP1-40787	Applications	Species
Artibani M, Sims AH, Slight J et al. WT1 expression in breast cancer disrupts the epithelial/mesenchymal balance of tumour cells and correlates with the metabolic response to docetaxel. Sci Rep. 2017-03-27 [PMID: 28345629] (WB, Human)	WB	Human
Fan Y, Li X, Xiao W et al. BAMBI elimination enhances alternative TGF-beta signaling and glomerular dysfunction in diabetic mice Diabetes. 2015-01-09 [PMID: 25576053] (IHC-P, Mouse) Details: WT-1 antibody used for IHC-P application with immunofluorescence detection on formalin fixed paraffin embedded sections from kidneys of BAMBI+/+ or -/- mice on C57BL/6 background expressing the histone yellow fluorescent protein under the control of the promotor of Vegfr-2/Flk1 gene (Supplemental Figure 2, last panel). WT1 stained the podocyte nuclei in the tested murine kidney sections.	IHC-P	Mouse
Anderberg RJ, Meek RL, Hudkins KL et al. Serum amyloid A and inflammation in diabetic kidney disease and podocytes. Lab. Invest. 2014-12-22 [PMID: 25531567]
Dai Yan, Gu Leyi, Yuan Weijie et al. Podocyte-specific deletion of signal transducer and activator of transcription 3 attenuates nephrotoxic serum-induced glomerulonephritis. Kidney Int 2013-01-01 [PMID: 23842188] (ICC/IF, Mouse)	ICC/IF	Mouse
Mallipattu SK, Liu R, Zhong Y et al. Expression of HIV transgene aggravates kidney injury in diabetic mice. Kidney Int 2013-01-16 [PMID: 23325078] (IF/IHC, Mouse)	IF/IHC	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Kelly Hudkins	IHC-P	Mouse	06/19/2012	View Summary Application Immunohistochemistry-Paraffin Sample Tested Mouse kidney, human kidney Species Mouse

Array NBP1-40787

• WT1 Antibodies
• WT1 ELISA Kits
• WT1 Lysate
• WT1 Proteins