ULK1 Products

Description

ULK1 belongs to the serine/threonine protein kinase family. It is involved in axon growth and plays an essential role in neurite branching during sensory axon outgrowth. Knockdown of ULK1 results in impaired endocytosis of nerve growth factor (NGF), excessive axon arborization, and severely stunted axon elongation indicating that ULK1 mediates a non clathrin coated endocytosis in sensory growth cones. Knockdown of ULK1 also inhibits the autophagic response. It appears to act as a convergence point for multiple signals that regulate autophagy, and in turn interacts with a large number of autophagy related (Atg) proteins.

Bioinformatics

Entrez	22241 Mouse 360827 Rat 8408 Human
Uniprot	AAI11604.1 Human NM_003565 Human NP_003556 Human NP_003556.1 Human O70405 Mouse O75385 Human
Product By Gene ID	8408
Alternate Names	ATG1 autophagy related 1 homolog ATG1 ATG1A EC 2.7.11 EC 2.7.11.1 FLJ38455 FLJ46475 KIAA0722 serine/threonine-protein kinase ULK1 unc-51 (C. elegans)-like kinase 1 UNC51 Unc51.1 unc-51-like kinase 1 (C. elegans) Unc-51-like kinase 1

Research Areas for ULK1

Find related products by research area and learn more about each of the different research areas below.

Autophagy
mTOR Pathway
Protein Kinase

Related ULK1 Blog Posts

Check out the latest blog posts on ULK1.

The Many Connections Between Autophagy and Kidney Disease By Yoskaly Lazo-Fernandez, PhD The first description of what is called today an autophagosome was given in a paper published in 1957. Its author employed electron microscopy to observe the neonatal features of mous...    Read more.

Autophagy independent roles of the core ATG proteins By Christina Towers, PhD. Autophagy and ATG ProteinsAutophagy is a nutrient recycling process that cells use to fuel metabolism, particularly in response to nutrient deprivation.  It is critical for removal of dam...    Read more.

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Animal Models to Study Autophagy By Christina Towers, PhD What is autophagy?Autophagy is the catabolic process that degrades cytoplasmic material via the lysosome. The process of macroautophagy was originally characterized in yeast, where the...    Read more.

Autophagy Research Update: What a difference a year makes! By Christina Towers, PhD Over the last two decades the field of autophagy has exploded! Innovative techniques, comprehensive analysis and disease-relevant models have yielded basic and clinical discoveries of conseque...    Read more.

ULK1 - mammalian homologue of the yeast ATG1 kinase Autophagy is an important cellular process involved in degradation and recycling of cellular macromolecules in response to stress or starvation. Autophagy is carried out in four main phases: phagophore nucleation, autophagosome elongation, docking...    Read more.

VPS34 - autophagy initiator and regulator of endosomal trafficking VPS34, vacuolar protein sorting 34, is the only identified Class III phosphoinositide-3 kinase (PI3K) in mammals and is ubiquitously expressed in all eukaryotic cells. VPS34 is a 100 kDa protein responsible for phosphorylating phosphatidylinositol...    Read more.

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