WDR79 Antibody

WD-repeat domain 79 (WDR79) contains six WD (tryptophan-aspartate) repeat domains found in a number of proteins that function as adaptor molecules in signal transduction and cytoskeletal organization. The WD repeat is defined by four or more repeating units of a conserved core of approximately 40 amino acids ending with tryptophan-aspartic acid (WD). WD repeats may serve as sites of protein-protein interaction for adaptor proteins and facilitate multiprotein complex formation. The function of the WDR79 protein has not been characterized, however significant and consistent single nucleotide polymorphisms in the WDR79 gene have been found to be associated with ER negative breast cancer.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: Chemotaxis, ICC/IF, IHC-P, WB.

Showing Publications 1 - 10 of 10.

Publications using NB100-68252	Applications	Species
Jian Qin, Alexandre Garus, Chantal Autexier The C-terminal extension of dyskerin is a dyskeratosis congenita mutational hotspot that modulates interaction with telomerase RNA and subcellular localization Human Molecular Genetics 2024-02-15 [PMID: 37879098]
Klump BM, Perez GI, Patrick EM et al. TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly Cell reports 2023-06-01 [PMID: 37267110]
Xu G, Yamamoto N, Nojima T, et al. HnRNP F/H associate with hTERC and telomerase holoenzyme to modulate telomerase function and promote cell proliferation Cell Death Differ. 2019-12-20 [PMID: 31863069] (WB, Human)	WB	Human
MacNeil, DE;Lambert-Lanteigne, P;Autexier, C; N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation Nucleic Acids Res. 2019-04-01 [PMID: 30931479] (WB, Human)	WB	Human
Vogan JM, Zhang X, Youmans DT et al. Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies. Elife. 2016-08-15 [PMID: 27525486] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Vogan JM, Collins K. Dynamics of Human Telomerase Holoenzyme Assembly and Subunit Exchange Across the CellCycle* . Cell cycle. 2015-07-13 [PMID: 26170453] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Schertzer M, Jouravleva K, Perderiset M et al. Human regulator of telomere elongation helicase 1 (RTEL1) is required for the nuclear and cytoplasmic trafficking of pre-U2 RNA Nucleic Acids Res. 2015-01-27 [PMID: 25628358]
Sun CK, Luo XB, Gou YP et al. TCAB1: a potential target for diagnosis and therapy of head and neck carcinomas. Mol. Cancer 2014-07-28 [PMID: 25070141] (WB, IHC-P, Human) Details: TCAB1/ WDR79 antibody used for WB (1:2000 dilution in 5% BSA) and IHC-P (Tris-EDTA antigen retrieval for 3-5 min at 100C, primary used at 1:200 dilution) in human head and neck carcinoma cell lines/xenograft and pathological specimens. Figure 1a - WB showing elevated expression of TCAB1 in head and neck cancer cell lines (CNE1, HSC-3, Cal27, ACC2) compared to human normal primary cells (PDLC, DPC); Figure 2b - WB of TCAB1 in Cal27 cells treated or not with exogenous shTCAB1 lentivirus for TCAB1 depletion; Figure 1c - TCAB1 IHC images of human nasopharyngeal carcinoma/NPC and nasopharyngitis/NPI tissues; Figure 4 - TCAB1 IHC staining of xenograft generated using shTCAB1-C and shScra cells.	WB, IHC-P	Human
Stern JL, Zyner KG, Pickett HA et al. Telomerase Recruitment Requires both TCAB1 and Cajal Bodies Independently Mol Cell Biol 2012-07-01 [PMID: 22547674] (Chemotaxis, ICC/IF, Human)	Chemotaxis, ICC/IF	Human
Mahmoudi S, Henriksson S, Farnebo L et al. WRAP53 promotes cancer cell survival and is a potential target for cancer therapy. Cell Death Dis 2011-01-01 [PMID: 21368886]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: I Sawyer	IF	Human	02/26/2016	View Summary Application Immunofluorescence Sample Tested hela Species Human Lot A1

Array NB100-68252

• WDR79 Antibodies
• WDR79 Lysates
• WDR79 Proteins