Trypsin 3/PRSS3 Antibody (420025)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human Trypsin 3, encoded by the PRSS3 gene, is also known as mesotrypsin (1). Constituting less than 10% of the total trypsin content in normal pancreatic juice, it is one of the three trypsin isoforms produced by the pancreas (2). Compared to trypsin 1 and 2, one intriguing feature of Trypsin 3 is its resistance to polypeptide trypsin inhibitors, such as the Kunitz-type soybean trypsin inhibitor or the Kazal-type pancreatic secretory trypsin inhibitor. As revealed by the crystal structure, this resistance is likely due to the presence of an arginine residue in place of the highly conserved Gly198 (3). Trypsin 3 is synthesized in the pancreas and secreted into the duodenum lumen, where it is activated by enterokinase. One proposed physiological function of Trypsin 3 is degradation of trypsin inhibitors, which facilitates the digestion of those foods rich in these proteins (4).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using MAB3710	Applications	Species
Bonan Lin, Xiaomeng Zhou, Shuye Lin, Xiaoyue Wang, Meiying Zhang, Baoping Cao et al. Epigenetic silencing of PRSS3 provides growth and metastasis advantage for human hepatocellular carcinoma Journal of Molecular Medicine 2017-11-01 [PMID: 28844099]

Array MAB3710

• Trypsin 3/PRSS3 Antibodies
• Trypsin 3/PRSS3 Protein
• Trypsin 3/PRSS3 Proteins and Enzymes