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TrkA Antibody (994307) [Janelia Fluor® 549]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, B/N, CyTOF-ready, ICC/IF
Clone
994307
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 549

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB1752U-100UG
Alexa Fluor 405
FAB1752V-100UG
Alexa Fluor 488
FAB1752G-100UG
Alexa Fluor 532
FAB1752X
Alexa Fluor 594
FAB1752T-100UG
Alexa Fluor 647
FAB1752R-100UG
Alexa Fluor 700
FAB1752N-100UG
Alexa Fluor 750
FAB1752S-100UG
Allophycocyanin
FAB1752A
Allophycocyanin/Cy7
FAB1752APCCY7
Biotin
FAB1752B
CoraFluor 1
FAB1752CL1
DyLight 350
FAB1752D
DyLight 405
FAB1752E
DyLight 488
FAB1752K
DyLight 550
FAB1752L
DyLight 594
FAB1752M
DyLight 650
FAB1752W
DyLight 680
FAB1752Y
DyLight 755
FAB1752Z
FITC
FAB1752F
HRP
FAB1752H
Janelia Fluor 525
FAB1752JF525
Janelia Fluor 585
FAB1752JF585
Janelia Fluor 635
FAB1752JF635
Janelia Fluor 646
FAB1752J
Janelia Fluor 669
FAB1752JF669
PE
FAB1752P
PE/Atto594
FAB1752PEATT594
PE/Cy5.5
FAB1752PECY55
PE/Cy7
FAB1752PECY7
PerCP
FAB1752C
Unconjugated
MAB1752-100
mFluor Violet 450 SE
FAB1752MFV450
mFluor Violet 500 SE
FAB1752MFV500
mFluor Violet 610 SE
FAB1752MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB1752-100
Carrier Free
MAB1752-100
Carrier Free
MAB1752-SP
Carrier Free
FAB1752V-100UG
Carrier Free
FAB1752U-100UG
Carrier Free
FAB1752T-100UG
Carrier Free
FAB1752S-100UG
Carrier Free
FAB1752R-100UG
Carrier Free
FAB1752N-100UG
Carrier Free
FAB1752G-100UG
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TrkA Antibody (994307) [Janelia Fluor® 549] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human TrkA
Ala33-Glu407
Accession # P04629
Specificity
Detects human TrkA in direct ELISAs.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Immunocytochemistry
  • Neutralization
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for TrkA Antibody (994307) [Janelia Fluor® 549]

  • DKFZp781I14186
  • EC 2.7.10
  • EC 2.7.10.1
  • MTChigh affinity nerve growth factor receptor
  • Neurotrophic tyrosine kinase receptor type 1
  • neurotrophic tyrosine kinase, receptor, type 1
  • NTRK1
  • NTRK-1
  • p140-TrkA
  • TRK1-transforming tyrosine kinase protein
  • TrkA
  • Trk-A
  • TRKAOncogene TRK
  • TRKTRK1
  • tyrosine kinase receptor A

Background

The Trk proto-oncogene encodes a 140 kDa, membrane-spanning protein tyrosine kinase that is expressed only in neural tissues. Nerve growth factor (NGF) stimulates phosphorylation of Trk A in neural cell lines and in embryonic dorsal root ganglia. Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that Trk A binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar. The identification of Trk A as an NGF receptor indicates that this protein participates in the primary signal transduction mechanism of NGF (1). Trk A was found to be expressed in the nervous system and phosphorylated in response to NGF (Nerve Growth Factor). Somatic rearrangement(s) of the TRKA gene (also designated NTRK1) are responsible for formation of some oncogenes (2). Trk A is expressed in neural and nonneuronal tissues. Like RET, Trk A is often activated by rearrangements that involve one of at least five other genes in papillary thyroid carcinoma (PTC) (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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TrkA Antibody
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FAB1752I
TrkA Antibody (994307) [Janelia Fluor® 549]
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FAQs for TrkA Antibody (FAB1752I). (Showing 1 - 1 of 1 FAQ).

  1. I am searching (with difficulty) for an antibody against Trka which can be used in flow cytometry. Since I am planning to use it for bead sorting of live cells it needs to be for a part of the receptor which is on the outside of the cell. Please can you let me know if you can help me with this.
    • NBP1-47436, NB100-98815 and NB100-65266 all bind to the extracellular domain of Trka, however, none of them are guaranteed for use in flow cytometry. Our only flow cytometry guaranteed antibodies bind to the intracellular domain. This does not mean one of these antibodies won't work for flow, we just can not guarantee it. If you would be interested in testing this novel application on one of our Trka antibodies, please take a look at our Innovators Reward Program.

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