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TrkA Antibody (165131R) [Janelia Fluor® 585]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, CyTOF-ready, KO
Clone
165131R
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 585

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB1751RU-100UG
Alexa Fluor 405
FAB1751RV-100UG
Alexa Fluor 488
FAB1751RG-100UG
Alexa Fluor 532
FAB1751RX
Alexa Fluor 594
FAB1751RT-100UG
Alexa Fluor 647
FAB1751RR-100UG
Alexa Fluor 700
FAB1751RN-100UG
Alexa Fluor 750
FAB1751RS-100UG
Allophycocyanin
FAB1751RA-100
Allophycocyanin/Cy7
FAB1751RAPCCY7
Biotin
FAB1751RB
CoraFluor 1
FAB1751RCL1
DyLight 350
FAB1751RD
DyLight 405
FAB1751RE
DyLight 488
FAB1751RK
DyLight 550
FAB1751RL
DyLight 594
FAB1751RM
DyLight 650
FAB1751RW
DyLight 680
FAB1751RY
DyLight 755
FAB1751RZ
FITC
FAB1751RF
HRP
FAB1751RH
Janelia Fluor 525
FAB1751RJF525
Janelia Fluor 549
FAB1751RI
Janelia Fluor 635
FAB1751RJF635
Janelia Fluor 646
FAB1751RJ
Janelia Fluor 669
FAB1751RJF669
PE/Atto594
FAB1751RPEATT594
PE/Cy5.5
FAB1751RPECY55
PE/Cy7
FAB1751RPECY7
PerCP
FAB1751RC
Phycoerythrin
FAB1751RP-100
Unconjugated
MAB1751R-100
mFluor Violet 450 SE
FAB1751RMFV450
mFluor Violet 500 SE
FAB1751RMFV500
mFluor Violet 610 SE
FAB1751RMFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB1751R-100
Carrier Free
MAB1751R-100
Carrier Free
MAB1751R-SP
Carrier Free
FAB1751RT-100UG
Carrier Free
FAB1751RS-100UG
Carrier Free
FAB1751RR-100UG
Carrier Free
FAB1751RV-100UG
Carrier Free
FAB1751RN-100UG
Carrier Free
FAB1751RU-100UG
Carrier Free
FAB1751RG-100UG
Carrier Free
FAB1751RA-100
Carrier Free
FAB1751RP-100
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TrkA Antibody (165131R) [Janelia Fluor® 585] Summary

Additional Information
Recombinant Monoclonal Antibody.
Immunogen
Mouse myeloma cell line NS0-derived recombinant human TrkA
Ala33-Glu407
Accession # P04629
Specificity
Detects human TrkA in direct ELISAs.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Knockout Validated
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for TrkA Antibody (165131R) [Janelia Fluor® 585]

  • DKFZp781I14186
  • EC 2.7.10
  • EC 2.7.10.1
  • MTChigh affinity nerve growth factor receptor
  • Neurotrophic tyrosine kinase receptor type 1
  • neurotrophic tyrosine kinase, receptor, type 1
  • NTRK1
  • NTRK-1
  • p140-TrkA
  • TRK1-transforming tyrosine kinase protein
  • TrkA
  • Trk-A
  • TRKAOncogene TRK
  • TRKTRK1
  • tyrosine kinase receptor A

Background

The Trk proto-oncogene encodes a 140 kDa, membrane-spanning protein tyrosine kinase that is expressed only in neural tissues. Nerve growth factor (NGF) stimulates phosphorylation of Trk A in neural cell lines and in embryonic dorsal root ganglia. Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that Trk A binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar. The identification of Trk A as an NGF receptor indicates that this protein participates in the primary signal transduction mechanism of NGF (1). Trk A was found to be expressed in the nervous system and phosphorylated in response to NGF (Nerve Growth Factor). Somatic rearrangement(s) of the TRKA gene (also designated NTRK1) are responsible for formation of some oncogenes (2). Trk A is expressed in neural and nonneuronal tissues. Like RET, Trk A is often activated by rearrangements that involve one of at least five other genes in papillary thyroid carcinoma (PTC) (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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TrkA Antibody
(165131R) [Janelia Fl ...
FAB1751RJF585
TrkA Antibody (165131R) [Janelia Fluor® 585]
Species: Hu
Applications: Flow, CyTOF-ready, KO

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FAQs for TrkA Antibody (FAB1751RJF585). (Showing 1 - 1 of 1 FAQ).

  1. I am searching (with difficulty) for an antibody against Trka which can be used in flow cytometry. Since I am planning to use it for bead sorting of live cells it needs to be for a part of the receptor which is on the outside of the cell. Please can you let me know if you can help me with this.
    • NBP1-47436, NB100-98815 and NB100-65266 all bind to the extracellular domain of Trka, however, none of them are guaranteed for use in flow cytometry. Our only flow cytometry guaranteed antibodies bind to the intracellular domain. This does not mean one of these antibodies won't work for flow, we just can not guarantee it. If you would be interested in testing this novel application on one of our Trka antibodies, please take a look at our Innovators Reward Program.

Secondary Antibodies

 

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Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its ...  Read full blog post.
TrkB: Docking for Neurotrophins and Beyond.
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...  Read full blog post.
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