Thymidylate Synthase Antibody (TYMS/1884) [FITC] Summary
Immunogen |
Recombinant human thymidylate synthase protein fragment (around aa 60-174) (exact sequence is proprietary) (Uniprot: P04818) |
Localization |
Nuclear & Cytoplasmic |
Marker |
5-FU Resistance Marker |
Isotype |
IgG2c Kappa |
Clonality |
Monoclonal |
Host |
Mouse |
Gene |
TYMS |
Purity |
Protein A or G purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Flow Cytometry
- Immunocytochemistry/ Immunofluorescence
- Immunohistochemistry
- Immunohistochemistry-Paraffin
- Protein Array
- Western Blot
|
Application Notes |
Optimal dilution of this antibody should be experimentally determined. |
Packaging, Storage & Formulations
Storage |
Store at 4C in the dark. |
Buffer |
PBS |
Preservative |
0.05% Sodium Azide |
Purity |
Protein A or G purified |
Alternate Names for Thymidylate Synthase Antibody (TYMS/1884) [FITC]
Background
Thymidylate synthase (TS) is an intracellular enzyme critical for de novo synthesis of DNA. In cancer, expression of TS is often elevated and becomes further elevated as a result of treatment with the most commonly used chemotherapeutic, 5-fluorouracil (5-FU). Resistance or lack of response to 5-FU is attributed to the elevation of TS activity. Overexpression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma and is usually predictive of shortened survival time.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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FAQs for Thymidylate Synthase Antibody (NBP3-08882F) (0)
Secondary Antibodies
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Isotype Controls
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