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Thymidylate Synthase Antibody (SPM453) [PE]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, CyTOF-ready
Clone
SPM453
Clonality
Monoclonal
Host
Mouse
Conjugate
PE

Order Details

Thymidylate Synthase Antibody (SPM453) [PE] Summary

Description
This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Immunogen
Recombinant full-length human Thymidylate Synthase protein. (Uniprot: P04818 )
Localization
Cytoplasm, Nucleus, Mitochondria
Marker
5-FU Resistance Marker
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TYMS
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow (Intracellular)
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Alternate Names for Thymidylate Synthase Antibody (SPM453) [PE]

  • EC 2.1.1.45
  • HsT422
  • MGC88736
  • OK/SW-cl.29
  • Thymidylate Synthase
  • thymidylate synthetase
  • TMSTsase
  • TS
  • TSase
  • TSHST422
  • TYMS

Background

Thymidylate synthase (TS) is an intracellular enzyme critical for de novo synthesis of DNA. In cancer, expression of TS is often elevated and becomes further elevated as a result of treatment with the most commonly used chemotherapeutic, 5-fluorouracil (5-FU). Resistance or lack of response to 5-FU is attributed to the elevation of TS activity. Overexpression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma and is usually predictive of shortened survival time.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol TYMS