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Thymidylate Synthase Antibody (SPM453) [Janelia Fluor® 585]

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Summary
Product Discontinued
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    • Catalog Number
      NBP2-34441JF585
    • Availability
      Product Discontinued

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Thymidylate Synthase Antibody (SPM453) [Janelia Fluor® 585] Summary

Immunogen
Recombinant full-length human Thymidylate Synthase protein. (Uniprot: P04818 )
Localization
Cytoplasm, Nucleus, Mitochondria
Marker
5-FU Resistance Marker
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TYMS
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow (Intracellular)
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Thymidylate Synthase Antibody (SPM453) [Janelia Fluor® 585]

  • EC 2.1.1.45
  • HsT422
  • MGC88736
  • OK/SW-cl.29
  • Thymidylate Synthase
  • thymidylate synthetase
  • TMSTsase
  • TS
  • TSase
  • TSHST422
  • TYMS

Background

Thymidylate synthase (TS) is an intracellular enzyme critical for de novo synthesis of DNA. In cancer, expression of TS is often elevated and becomes further elevated as a result of treatment with the most commonly used chemotherapeutic, 5-fluorouracil (5-FU). Resistance or lack of response to 5-FU is attributed to the elevation of TS activity. Overexpression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma and is usually predictive of shortened survival time.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol TYMS