TACE/ADAM17 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TACE is a member of the ADAM family that contains A Disintegrin And Metalloprotease-like domain. Like other membrane-anchored ADAMs, TACE consists of a pro domain with a cysteine switch and furin cleavage sequence, a catalytic domain with the zinc-binding site and Met-turn expected for reprolysins, a disintegrin-like domain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and the cytoplasmic domain. In addition to its ability to release the 17 kDa extracellular form of tumor necrosis factor-alpha (TNF-alpha ) from the 26 kDa membrane-anchored TNF-alpha , TACE also plays an essential role in shedding ectodomains from a variety of proteins such as L-Selectin, Transforming Growth Factor-alpha , Amyloid Protein Precursor, and Notch-1 receptor. TACE mRNA is present in virtually every tissue and TACE protein resides both on the cell surface and in the cell.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Canine, Primate - Cholrocebus pygerythrus (Vervet Monkey).

We have publications tested in 2 applications: Immunoprecipitation, Western Blot.

Showing Publications 1 - 4 of 4.

Publications using AF930	Applications	Species
PS Caceres, D Gravotta, PJ Zager, N Dephoure, E Rodriguez- Quantitative proteomics of MDCK cells identify unrecognized roles of clathrin adaptor AP-1 in polarized distribution of surface proteins Proc. Natl. Acad. Sci. U.S.A., 2019-05-29;116(24):11796-11805. 2019-05-29 [PMID: 31142645] (Western Blot, Canine)	Western Blot	Canine
Tellier E, Rebsomen L The shedding activity of ADAM17 is sequestered in lipid rafts. Exp. Cell Res., 2006-09-05;312(20):3969-80. 2006-09-05 [PMID: 17010968] (Western Blot, Human, Mouse, Primate - Cholrocebus pygerythrus (Vervet Monkey))	Western Blot	Human, Mouse, Primate - Cholrocebus pygerythrus (Vervet Monkey)
Canault M, Tellier E, Bonardo B, Mas E, Aumailley M, Juhan-Vague I, Nalbone G, Peiretti F FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity. J. Cell. Physiol., 2006-08-01;208(2):363-72. 2006-08-01 [PMID: 16619241] (Immunoprecipitation, Human)	Immunoprecipitation	Human
Ito N, Nomura S, Iwase A, Ito T, Kikkawa F, Tsujimoto M, Ishiura S, Mizutani S ADAMs, a disintegrin and metalloproteinases, mediate shedding of oxytocinase. Biochem. Biophys. Res. Commun., 2004-02-20;314(4):1008-13. 2004-02-20 [PMID: 14751233] (Western Blot, Human)	Western Blot	Human

Array AF930

• TACE/ADAM17 Antibodies
• TACE/ADAM17 ELISA Kits
• TACE/ADAM17 Proteins
• TACE/ADAM17 ELISA
• TACE/ADAM17 Proteins and Enzymes