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TACE/ADAM17 Antibody (136133) [DyLight 488]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP, CyTOF-ready, Flow, KO
Clone
136133
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 488

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB21291U-100UG
Alexa Fluor 405
FAB21291V-100UG
Alexa Fluor 488
FAB21291G-100UG
Alexa Fluor 532
FAB21291X
Alexa Fluor 594
FAB21291T-100UG
Alexa Fluor 647
FAB21291R-100UG
Alexa Fluor 700
FAB21291N-100UG
Alexa Fluor 750
FAB21291S-100UG
Allophycocyanin
FAB21291A
Biotin
FAB21291B
DyLight 350
FAB21291D
DyLight 405
FAB21291E
DyLight 550
FAB21291L
DyLight 594
FAB21291M
DyLight 650
FAB21291W
DyLight 680
FAB21291Y
DyLight 755
FAB21291Z
FITC
FAB21291F
HRP
FAB21291H
Janelia Fluor 525
FAB21291JF525
Janelia Fluor 549
FAB21291I
Janelia Fluor 585
FAB21291JF585
Janelia Fluor 635
FAB21291JF635
Janelia Fluor 646
FAB21291J
Janelia Fluor 669
FAB21291JF669
PE
FAB21291P
PerCP
FAB21291C
Unconjugated
MAB21291
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB21291
Carrier Free
MAB21291
Carrier Free
MAB21291-SP
Carrier Free
FAB21291V-100UG
Carrier Free
FAB21291U-100UG
Carrier Free
FAB21291T-100UG
Carrier Free
FAB21291S-100UG
Carrier Free
FAB21291R-100UG
Carrier Free
FAB21291N-100UG
Carrier Free
FAB21291G-100UG
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TACE/ADAM17 Antibody (136133) [DyLight 488] Summary

Immunogen
E. coli-derived recombinant human TACE/ADAM17
Asp695-Cys824
Accession # P78536
Specificity
Detects human TACE/ADAM17 Cytosolic Domain in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human ADAM33 is observed.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ADAM17
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Immunoprecipitation
  • Intracellular Staining by Flow Cytometry
  • Knockout Validated
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

0

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for TACE/ADAM17 Antibody (136133) [DyLight 488]

  • ADAM 17
  • ADAM metallopeptidase domain 17
  • ADAM metallopeptidase domain 18
  • ADAM17
  • ADAM18
  • CD156b antigen
  • CD156b
  • CSVP
  • disintegrin and metalloproteinase domain-containing protein 17
  • EC 3.4.24.86
  • MGC71942
  • Snake venom-like protease
  • TACE
  • TACEcSVP
  • TNF-alpha convertase
  • TNF-alpha converting enzyme
  • TNF-alpha-converting enzyme
  • tumor necrosis factor, alpha, converting enzyme

Background

ADAM17 encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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TACE/ADAM17
Antibody (136133) [Dy ...
FAB21291K
TACE/ADAM17 Antibody (136133) [DyLight 488]
Species: Hu
Applications: WB, IP, CyTOF-ready, Flow, KO

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Bioinformatics

Gene Symbol ADAM17