Synapsin I [p Ser549] Antibody

Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002). Ser 549 along with Ser 62 and Ser 67 are the sites of Synapsin I that are phosphorylated by MAP kinase (Jovanovic et al., 1996). Phosphorylation and subsequent dephosphorylation of this site is thought to play a key role in synaptic vesicle trafficking.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 3 of 3.

Publications using NB300-744	Applications	Species
Provenzano G, Pangrazzi L, Poli A et al. Reduced phosphorylation of synapsin I in the hippocampus of Engrailed-2 knockout mice, a model for autism spectrum disorders. Neuroscience. 2014-11-25 [PMID: 25463523] (IF/IHC, Mouse)	IF/IHC	Mouse
Chan B, Cottrell JR, Li B et al. Development of a High-Throughput AlphaScreen Assay for Modulators of Synapsin I Phosphorylation in Primary Neurons. J Biomol Screen. 2013-10-02 [PMID: 24088370] (WB, Rat)	WB	Rat
Cottrell JR, Levenson JM, Kim SH et al. Working Memory Impairment in Calcineurin Knock-out Mice Is Associated with Alterations in Synaptic Vesicle Cycling and Disruption of High-Frequency Synaptic and Network Activity in Prefrontal Cortex. J Neurosci. 2013-07-03 [PMID: 23825400]

Array NB300-744

• Synapsin I Antibodies
• Synapsin I Lysate
• Synapsin I Protein