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SOST/Sclerostin Antibody (220902) [Unconjugated]

 (14 Publications)
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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA(Cap)
Clone
220902
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB1406-SP
Carrier Free
MAB1406-500
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SOST/Sclerostin Antibody (220902) [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human SOST/Sclerostin
Gln24-Tyr213
Accession # Q9BQB4
Specificity
Detects human SOST/Sclerostin in ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse SOST is observed.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
SOST
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.5-2.0 ug/mL
  • ELISA Standard (Matched Pair)
  • Western Blot 1 ug/mL
Application Notes
ELISA Capture: Human SOST/Sclerostin Antibody (Catalog # MAB1406)
ELISA Detection: Human SOST/Sclerostin Biotinylated Antibody (Catalog # BAM14061)
Standard: Recombinant Human SOST/Sclerostin (Catalog # 1406-ST)
Publications
Read Publications using
MAB1406 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SOST/Sclerostin Antibody (220902) [Unconjugated]

  • sclerostin
  • SOST
  • VBCHsclerosteosis

Background

SOST, also known as sclerostin, belongs to the Cerberus/DAN family of secreted glycoproteins. SOST binds BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity and functions in bone homeostasis as a BMP antagonist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SOST/Sclerostin Antibody (MAB1406)(14)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: ELISA Development, ICC, IHC, IHC-P, Western Blot.


Filter By Application
ELISA Development
(2)
ICC
(1)
IHC
(2)
IHC-P
(1)
Western Blot
(3)
All Applications
Filter By Species
Human
(6)
Mouse
(2)
All Species
Showing Publications 1 - 10 of 14. Show All 14 Publications.
Publications using MAB1406 Applications Species
N Kurgan, B Baranowski, J Stoikos, AJ MacNeil, VA Fajardo, REK MacPherson, P Klentrou Characterization of sclerostin's response within white adipose tissue to an obesogenic diet at rest and in response to acute exercise in male mice Frontiers in Physiology, 2023-01-04;13(0):1061715. 2023-01-04 [PMID: 36685192] (Western Blot, Mouse) Western Blot Mouse
VK Kuna, A Lundgren, LO Anerillas, P Kelk, M Brohlin, M Wiberg, PJ Kingham, LN Novikova, G Andersson, LN Novikov Efficacy of Nerve-Derived Hydrogels to Promote Axon Regeneration Is Influenced by the Method of Tissue Decellularization International Journal of Molecular Sciences, 2022-08-06;23(15):. 8/6/2022 [PMID: 35955880]
N Kurgan, H Islam, JBL Matusiak, BJ Baranowski, J Stoikos, VA Fajardo, REK MacPherson, BJ Gurd, P Klentrou Subcutaneous adipose tissue sclerostin is reduced and Wnt signaling is enhanced following 4-weeks of sprint interval training in young men with obesity Physiological Reports, 2022-03-01;10(6):e15232. 3/1/2022 [PMID: 35312183]
Qiushi Wei, Bin Wang, Hailan Hu, Chuhai Xie, Long Ling, Jianliang Gao et al. Icaritin promotes the osteogenesis of bone marrow mesenchymal stem cells via the regulation of sclerostin expression International Journal of Molecular Medicine 2020-01-20 [PMID: 31985018]
CJM Stapledon, H Tsangari, LB Solomon, DG Campbell, P Hurtado, R Krishnan, GJ Atkins Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulphate Sodium (PPS) and implications for pain associated with knee osteoarthritis PLoS ONE, 2019-09-26;14(9):e0222602. 2019-09-26 [PMID: 31557169] (ICC, Human) ICC Human
Yusuke Inagaki, Edward S Hookway, Takeshi G Kashima, Mitsuru Munemoto, Yasuhito Tanaka, Andrew Bassim Hassan et al. Sclerostin expression in bone tumours and tumour-like lesions Histopathology 2016-09-01 [PMID: 26896083]
Pereira R, Valta H, Tumber N, Salusky I, Jalanko H, Makitie O, Wesseling Perry K Altered Osteocyte-Specific Protein Expression in Bone after Childhood Solid Organ Transplantation. PLoS ONE, 2015-09-21;10(9):e0138156. 2015-09-21 [PMID: 26390291] (IHC, Human) IHC Human
Agnetha Folestad, Martin Ålund, Susanne Asteberg, Jesper Fowelin, Ylva Aurell, Jan Göthlin et al. Role of Wnt/ beta -catenin and RANKL/OPG in bone healing of diabetic Charcot arthropathy patients Acta Orthopaedica 2015-07-21 [PMID: 25811776]
Pereira R, Juppner H, Gales B, Salusky I, Wesseling-Perry K Osteocytic protein expression response to doxercalciferol therapy in pediatric dialysis patients. PLoS ONE, 2015-03-16;10(3):e0120856. 2015-03-16 [PMID: 25774916] (IHC, Human) IHC Human
Daniel Cejka, Johann Herberth, Adam J. Branscum, David W. Fardo, Marie-Claude Monier-Faugere, Danielle Diarra et al. Sclerostin and Dickkopf-1 in Renal Osteodystrophy Clinical Journal of the American Society of Nephrology 2011-04-01 [PMID: 21164019]
Show All 14 Publications.

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Bioinformatics

Gene Symbol SOST
Uniprot