Antibody was raised against a 17 amino acid synthetic peptide from near the center of human SLPI. The immunogen is located within amino acids 60 - 110 of SLPI. Amino Acid Squence: CLDPVDTPNPTRRKPGK
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SLPI
Purity
Peptide affinity purified
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Use in ICC/IF reported in scientific literature (PMID: 28597116).
Theoretical MW
19 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Secretory leukocyte protease inhibitor (SLPI) is produced at mucosal surfaces, primarily the upper respiratory tract and is thought to play an important role in the antiprotease defense mechanism of the lung. SLPI forms inhibitory complexes with numerous proteolytic enzymes such as neutrophil elastase, and has been shown to possess anti-inflammatory, anti-viral, and antibacterial activities. Its expression in oral epithelial cells is stimulated by HIV-1 gp120, suggesting that SLPI is a component of the oral mucosal response to HIV-1. In peripheral blood monocytes, SLPI can inhibit NF-kappaB activation by inhibiting IkappaB degradation in the cytoplasm and competing for NF-kappaB binding sites in the nucleus. This attenuation of the inflammatory response may also act to suppress liver metastases and other cancer cell invasions, but promote blood-borne metastasis via an invasion-independent pathway.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Publications for SLPI Antibody (NBP1-76803)(3)
We have publications tested in 2 confirmed species: Human, Mouse.
We have publications tested in 4 applications: ICC/IF, IF/ICC, IHC-P, WB.
FAQs for SLPI Antibody (NBP1-76803). (Showing 1 - 1 of 1 FAQs).
What is the molecular weight of SLPI?
Here is information about this protein, UniProt P03973. Its theoretical MW is approximately 14 kDa. In our western blot testing with this antibody, we picked up the band a little bit higher than this, which is could be due to post translational modification.
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![Western Blot: SLPI Antibody [NBP1-76803] - Daudi cell lysate with SLPI antibody at (A) 1 and (B) 2 ug/mL.](http://images.novusbio.com/fullsize/SLPI-Antibody-Western-Blot-NBP1-76803-img0001.jpg "Western Blot: SLPI Antibody [NBP1-76803] - Daudi cell lysate with SLPI antibody at (A) 1 and (B) 2 ug/mL.")
![Immunohistochemistry-Paraffin: SLPI Antibody [NBP1-76803] - Mouse lung tissue with SLPI antibody at 10 ug/ml.](http://images.novusbio.com/fullsize/SLPI-Antibody-Immunohistochemistry-Paraffin-NBP1-76803-img0002.jpg "Immunohistochemistry-Paraffin: SLPI Antibody [NBP1-76803] - Mouse lung tissue with SLPI antibody at 10 ug/ml.")
![Western Blot: Goat anti-Rabbit IgG (H+L) Secondary Antibody [HRP] [NB7160] - Western blot showing vemurafenib treatment in BRAFV600E CRC cells inhibits fission mediator DRP1 with no significant effect on fusion proteins (Mfn1 & 2) using MFN-1 antibody (NBP1-51841) and corresponding secondary antibody, goat anti-rabbit IgG-HRP (NB7160). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/33738242).](https://images.novusbio.com/images/Goat-anti-Rabbit-IgG-H+L-Secondary-Antibody-HRP-Western-Blot-NB7160-img0001.jpg "Western Blot: Goat anti-Rabbit IgG (H+L) Secondary Antibody [HRP] [NB7160] - Western blot showing vemurafenib treatment in BRAFV600E CRC cells inhibits fission mediator DRP1 with no significant effect on fusion proteins (Mfn1 & 2) using MFN-1 antibody (NBP1-51841) and corresponding secondary antibody, goat anti-rabbit IgG-HRP (NB7160). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/33738242).")
![Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - Intracellular FACS analysis of mouse TLR6 polyclonal antibody (red), rabbit isotype control (green), RAW cells alone (shaded). Two micrograms of antibodies were used. Goat anti-rabbit FITC (Novus, 20302) was used as secondary.](https://images.novusbio.com/images/Rabbit--Mouse-IgG-Isotype-Control-Flow-Cytometry-NBP2-24891-img0001.jpg "Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - Intracellular FACS analysis of mouse TLR6 polyclonal antibody (red), rabbit isotype control (green), RAW cells alone (shaded). Two micrograms of antibodies were used. Goat anti-rabbit FITC (Novus, 20302) was used as secondary.")