SIRT7 Antibody

SIRT7 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publication 1 - 1 of 1.

Publication using NB100-56364	Applications	Species
Alhazzazi TY, Kamarajan P, Joo N et al. Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. Cancer. 2011-04-15 [PMID: 21472714] (WB, Human) Details: WB: SIRT4 (IMG-3580), SIRT5 (IMG-479), SIRT7 (IMG-425). Oral squamous cell carcinoma; HSC-3, UM-SCC-1, UM-SCC-17B,and normal human oral keratinocyets (k), Fig 1A.	WB	Human

Array NB100-56364

• SIRT7 Antibodies
• SIRT7 ELISA Kits
• SIRT7 Lysate
• SIRT7 Protein