Recombinant Mouse ASGR2 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Asialoglycoprotein receptor 2 (ASGR2), also known as hepatic lectin 2 (HL-2), is an approximately 38 kDa member of the C-type lectin receptor family (1). ASGR2 is a single-pass type II transmembrane protein that plays a role in the endocytosis of desialylated glycoproteins, hepatic thrombopoietin production, and gastrointestinal malignancies (2, 3). ASGR2 is closely related to ASGR1 which is about 2 kDa smaller and is encoded by distinct but closely linked genes. Variations in ASGR2 structure due to alternative splicing have been reported (4-6). Mature ASGR2 consists of a cytoplasmic domain, transmembrane segment and an extracellular domain (ECD). Within the ECD, mouse ASGR2 shares 67% and 83% aa sequence identity with human and rat ASGR2, respectively. Both ASGR2 and ASGR1 compose the asialoglycoprotein receptor (ASGPR) which mediates removal of potentially hazardous glycoconjugates from blood in health and disease (7). ASGPR, also known as the Ashwell receptor, can modulate von Willebrand factor (vWF) and platelet homeostasis in part via clearance of platelets that are first desialylated during sepsis caused by pathogens including S. pneumoniae. The ASGR1 chain of the Ashwell receptor participates in plasma vWF clearance independently of sialylation and sepsis, ASGR2 colocalization with plasma vWF was increased in ASGR1 deficient mice (8). In addition, ASGR2 expression was shown to be associated with malignant phenotypes in gastric cancer and may represent a specific biomarker for recurrence of some gastric cancers (9).

Array 10447-AS

• Asialoglycoprotein Receptor 2 Antibodies
• Asialoglycoprotein Receptor 2 ELISA Kit
• Asialoglycoprotein Receptor 2 Lysates
• Asialoglycoprotein Receptor 2 Proteins
• Asialoglycoprotein Receptor 2 Proteins and Enzymes