Recombinant Human TfR2 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Transferrin Receptor 2 (TfR2 or TfR2 alpha) is an iron-binding type 2 transmembrane glycoprotein homologous to the Transferrin Receptor 1 (TfR or TfR1) (1). It forms a 215 kDa disulfide-linked homodimer and is predominantly expressed in the liver and modulates hepcidin production in response to iron (1, 2). Human TfR2 cDNA encodes 801 amino acids (aa) including an 83 aa N-terminal intracellular region, a 21 aa transmembrane domain, and a 697 aa extracellular domain (ECD). Human TfR2 ECD shares 86% and 45% aa identity with mouse TfR2 and human TfR1, respectively. An alternative splicing isoform (TfR2 beta) lacks the intracellular region, transmembrane domain and part of the extracellular regions and is expressed ubiquitously (1, 3). The Iron loaded Transferrin (holo-Transferrin) circulating in blood binds to cell-surface receptor TFR2 (4). Mutations in TFR2 can cause a form of hereditary hemochromatosis (HH, type 111), a disorder marked by chronic iron overload (5). 

Array 10486-TF

• TfR2 Antibodies
• TfR2 ELISA Kits
• TfR2 Lysate
• TfR2 Protein
• TfR2 Proteins and Enzyme