Recombinant Human Proprotein Convertase 9/PCSK9 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

PCSK9 (proprotein convertase subtilisin kexin 9), also known as NARC-1, is a member of the proteinase K subfamily of subtilisin-related serine endoproteases. It is highly expressed in the liver, intestine, and kidney and plays an important role in regulating LDL R expression and circulating cholesterol levels (1). PCSK9 is synthesized as precursor protein that is autocatalytically cleaved in the endoplasmic reticulum to generate a 14 kDa prodomain and a 60 kDa catalytic domain (2). Within the secretion pathway, the prodomain remains associated with and functions as a chaperone for the catalytic domain (2). Although the other members of the proprotein convertase family demonstrate activity on several downstream targets, PCSK9 protease activity has only been demonstrated through its autocatalytic processing (3). PCSK9 plays a key role in the regulation of cholesterol metabolism by binding to hepatic LDL R, LRP-1, VLDL R, and Apolipoprotein E R2 and promoting their lysosomal degradation instead of recycling to the plasma membrane (4-7). It can also regulate cholesterol and triglyceride handling in the intestine and adipose tissue (8-10). These reported functions create significant interest in PCSK9 as a pharmacological target in cardiovascular disease (11). PCSK9 has been reported to interact with non-LDR targets as well, including mediators of inflammation and immunological processes (12).

Array AVI3888

• Proprotein Convertase 9/PCSK9 Antibodies
• Proprotein Convertase 9/PCSK9 Antibody Pairs
• Proprotein Convertase 9/PCSK9 ELISA Kits
• Proprotein Convertase 9/PCSK9 Lysate
• Proprotein Convertase 9/PCSK9 Proteins and Enzymes
• Proprotein Convertase 9/PCSK9 ELISAs