Recombinant Human Histamine N-Methyltransferase/HNMT, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Histamine N-Methyltransferase (HNMT) catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the N_e2 atom of the imidazole ring in histamine producing methylhistamine (1). Because histamine is a potent mediator of numerous biological events, including the development of allergic inflammation, termination of its action by N-methylation is important event. Two major pathways exist for the inactivation of histamine in mammals (2). The pathway of histamine inactivation through HNMT plays a major role in bronchial epithelial and endothelial cells of the human airways and gut and HNMT is the only enzyme responsible for termination of the neurotransmitter action of histamine in the brain. The human HNMT gene contains a common single nucleotide polymorphism (SNP) that codes for either threonine or isoleucine at residue 105 (3). The 105I variant has decreased activity and lower protein levels relative to 105T. This SNP does not pose a serious risk for histamine accumulation (4).

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Bioassay.

Showing Publication 1 - 1 of 1.

Publication using 7637-MT	Applications	Species
HH Maw, X Zeng, S Campbell, ME Taub, AM Teitelbaum N-methylation of BI 187004 by thiol S-methyltransferase Drug Metab. Dispos., 2018-03-07;0(0):. 2018-03-07 [PMID: 29514826] (Bioassay, Human)	Bioassay	Human

Array 7637-MT

• Histamine N-Methyltransferase/HNMT Antibodies
• Histamine N-Methyltransferase/HNMT Lysate
• Histamine N-Methyltransferase/HNMT Proteins
• Histamine N-Methyltransferase/HNMT Proteins and Enzyme