Recombinant Human CEACAM-8/CD66b Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM-8), also known as CGM6 and CD66b, is an approximately 95 kDa member of the human carcinoembryonic antigen (CEA) family that plays a role in cell adhesion, cell migration and pathogen binding (1, 2). CEACAM-8 is anchored to cells by a glycophosphatidylinositol (GPI) motif and is expressed exclusively on granulocytes (3, 4). Human CEACAM-8 is composed of a 34 amino acid (aa) signal peptide, a 29 aa propeptide segment which is removed in the mature form, and a 286 aa CEACAM-8 region containing one V-type and two C2-type Ig-like domains (5). A homologue for CEACAM-8 has not been identified in the mice or rats (1). Activation enhances surface expression of CEACAM-8 and is an activation marker in human neutrophils and eosinophils (1, 6, 7). Engagement of CEACAM-8 by mAb or galectin-3 activated a Src family kinase (lyn), and induced cellular adhesion, superoxide production, and degranulation of eosinophils (1). CEACAM-8 can form both homotypic, and heterotypic bonds with CEACAM-6 through interaction of the V-type Ig-like domains (7-9). Cross-linking of neutrophil CEACAM-8 augments cytokine secretion and beta2 integrin-mediated adhesion (10, 11).

Array 9639-CM

• CEACAM8/CD66b Antibodies
• CEACAM8/CD66b ELISA Kits
• CEACAM8/CD66b Lysate
• CEACAM8/CD66b Proteins and Enzyme