Recombinant Human CD5 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD5, also known as Leu-1, Ly-1, and T1, is a 67 kDa transmembrane glycoprotein in the scavenger receptor superfamily (1). Mature human CD5 consists of a 348 amino acid (aa) extracellular domain (ECD) with three scavenger receptor cysteine-rich (SRCR) domains, a 30 aa transmembrane segment, and a 93 aa cytoplasmic domain (2). Within the ECD, human CD5 shares 55% aa sequence identity with mouse and rat CD5. The 52 kDa ECD can be cleaved from the cell surface and circulates in the serum (3). CD5 has been shown to interact homophilically, with CD72 on B cells, and with beta-glucan components of fungal cell walls (4‑6). CD5 expression on developing thymocytes is positively regulated by signaling through the T cell antigen receptor (TCR) and is up‑regulated on tolerized peripheral CD4⁺ cells (7, 8). It inhibits TCR signaling and promotes T cell nonresponsiveness and survival (8‑10). CD5 signaling inhibits the generation of regulatory T cells but promotes the development of Th17 cells (11, 12). Within the B cell lineage, CD5 is expressed on B-1a cells, anergic B cells, and IL-10 producing regulatory B cells (13‑16). Similarly to on T cells, it negatively regulates signaling through the B cell antigen receptor and supports peripheral B cell survival, anergy, and tolerance (13, 14, 16). B cells can produce an intracellularly-retained form of CD5 which lacks the signal peptide and a portion of the first SRCR domain (17). CD5 is also involved in the cellular entry of hepatitis C virus into T cells (18).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Bioassay, ELISA Capture.

Showing Publications 1 - 2 of 2.

Publications using 1636-CD	Applications	Species
L Sanchez-Mo, T Paul, C Martori, J Font-Díaz, L Sanjurjo, G Aran, É Téllez, J Blanco, J Carrillo, M Ito, M Tuttolomon, HJ Ditzel, C Fumagalli, G Tapia, J Sidorova, H Masnou, MA Fernández-, JJ Lozano, C Vilaplana, A Rodriguez-, C Armengol, AF Valledor, L Kremer, MR Sarrias Macrophage CD5L is a target for cancer immunotherapy EBioMedicine, 2023-04-11;91(0):104555. 2023-04-11 [PMID: 37054630] (ELISA Capture, Mouse)	ELISA Capture	Mouse
S Aparicio-S, M Deseke, A Lickert, C Garbers Trans-signaling of interleukin-6 (IL-6) is mediated by the soluble IL-6 receptor, but not by soluble CD5 Biochem. Biophys. Res. Commun, 2017-01-31;0(0):. 2017-01-31 [PMID: 28159554] (Bioassay)	Bioassay

Array 1636-CD

• CD5 Antibodies
• CD5 Antibody Pair
• CD5 Lysate
• CD5 Proteins
• CD5 Proteins and Enzymes