Recombinant Human ASGR2/ASGPR2 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Asialoglycoprotein receptor 2 (ASGR-2), also known as C-type lectin domain family 4 member H2 (CLEC4H2) and hepatic lectin H2 (HL-2), is an approximately 48 kDa member of the C-type lectin receptor family (1, 2). ASGR-2 is a single-pass type II transmembrane protein that plays a role in the endocytosis of desialylated glycoproteins and hepatic thrombopoietin production (3). ASGR-2 is closely related to ASGR-1 which is about 2 kDa smaller and is encoded by distinct but closely linked genes. Variations in ASGR-2 structure due to alternative splicing have been reported (4-6). Mature ASGR-2 consists of a 5 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment and a 232 aa extracellular domain (ECD). Within the ECD, human ASGR-2 shares 66% and 62% aa sequence identity with mouse and rat ASGR-2, respectively. Both ASGR-2 and ASGR-1 compose the asialoglycoprotein receptor (ASGPR) which mediates removal of potentially hazardous glycoconjugates from blood in health and disease (7). ASGPR, also known as the Ashwell receptor, can modulate von Willebrand factor (vWF) and platelet homeostasis in part through clearance of platelets that are first desialylated during sepsis caused by pathogens including S. pneumoniae. The ASGR-1 chain of the Ashwell receptor can also participate in plasma vWF clearance independently of sialylation and sepsis, ASGR-2 colocalization with plasma vWF was increased in ASGR-1 deficient mice (8). In addition, ASGR-2 expression was shown to be associated with malignant phenotypes in gastric cancer and may represent a specific biomarker for recurrence of some gastric cancers (9).

Array 9370-AS

• Asialoglycoprotein Receptor 2 Antibodies
• Asialoglycoprotein Receptor 2 ELISA Kit
• Asialoglycoprotein Receptor 2 Lysates
• Asialoglycoprotein Receptor 2 Proteins
• Asialoglycoprotein Receptor 2 Proteins and Enzymes