Podocalyxin Like Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Podocalyxin, also known as Podocalyxin-like protein-1 (PCLP1 or PODXL), is a type I transmembrane glycoprotein. It belongs to the CD34/Podocalyxin family of sialomucins that share structural similarity and sequence homology. Podocalyxin is a major sialoprotein in the podocytes of the kidney glomerulus and is also expressed by both endothelium and multipotent hematopoietic progenitors. It has been identified as a novel cell surface marker for hemangioblasts, the common precursors of hematopoietic and endothelial cells (1, 2).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 8 applications: Flow Cytometry, ICC, IHC, IHC-Fr, IHC-P, Immunocytochemistry, Immunohistochemistry, Western Blot.

Showing Publications 1 - 10 of 37. Show All 37 Publications. Collapse Publications.

Publications using AF1658	Applications	Species
Hong, S;Song, M;Miyoshi, T;Morizane, R;Bonventre, JV;Lee, LP; Dynamic Kidney Organoid Microphysiological Analysis Platform bioRxiv : the preprint server for biology 2024-10-29 [PMID: 39554191] (Immunocytochemistry, Human)	Immunocytochemistry	Human
Lebas, M;Chinigò, G;Courmont, E;Bettaieb, L;Machmouchi, A;Goveia, J;Beatovic, A;Van Kerckhove, J;Robil, C;Angulo, FS;Vedelago, M;Errerd, A;Treps, L;Gao, V;Delgado De la Herrán, HC;Mayeuf-Louchart, A;L'homme, L;Chamlali, M;Dejos, C;Gouyer, V;Garikipati, VNS;Tomar, D;Yin, H;Fukui, H;Vinckier, S;Stolte, A;Conradi, LC;Infanti, F;Lemonnier, L;Zeisberg, E;Luo, Y;Lin, L;Desseyn, JL;Pickering, J;Kishore, R;Madesh, M;Dombrowicz, D;Perocchi, F;Staels, B;Pla, AF;Gkika, D;Cantelmo, AR; Integrated single-cell RNA-seq analysis reveals mitochondrial calcium signaling as a modulator of endothelial-to-mesenchymal transition Science advances 2024-08-09 [PMID: 39121218] (Immunocytochemistry, Human)	Immunocytochemistry	Human
Liu, M;Zhang, C;Gong, X;Zhang, T;Lian, MM;Chew, EGY;Cardilla, A;Suzuki, K;Wang, H;Yuan, Y;Li, Y;Naik, MY;Wang, Y;Zhou, B;Soon, WZ;Aizawa, E;Li, P;Low, JH;Tandiono, M;Montagud, E;Moya-Rull, D;Rodriguez Esteban, C;Luque, Y;Fang, M;Khor, CC;Montserrat, N;Campistol, JM;Izpisua Belmonte, JC;Foo, JN;Xia, Y; Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo Cell stem cell 2024-01-04 [PMID: 38181751] (Immunohistochemistry, Human)	Immunohistochemistry	Human
Arend W. Overeem, Yolanda W. Chang, Ioannis Moustakas, Celine M. Roelse, Sanne Hillenius, Talia Van Der Helm et al. Efficient and scalable generation of primordial germ cells in 2D culture using basement membrane extract overlay Cell Reports Methods 2023-06-26 [PMID: 37426764]
Chen, Y;Gong, C;Chauhan, S;De La Cruz, ED;Datta, MS;Tomer, R; Scalable projected Light Sheet Microscopy for high-resolution imaging of large samples bioRxiv : the preprint server for biology 2023-06-05 [PMID: 37333196] (Immunohistochemistry, Human)	Immunohistochemistry	Human
S Cui, X Fang, H Lee, YJ Shin, ES Koh, S Chung, HS Park, SW Lim, KI Lee, JY Lee, CW Yang, BH Chung Modeling of Fabry disease nephropathy using patient derived human induced pluripotent stem cells and kidney organoid system Journal of Translational Medicine, 2023-02-22;21(1):138. 2/22/2023 [PMID: 36814269]
K Hiratsuka, T Miyoshi, KT Kroll, NR Gupta, MT Valerius, T Ferrante, M Yamashita, JA Lewis, R Morizane Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery Science Advances, 2022-09-21;8(38):eabq0866. 2022-09-21 [PMID: 36129975] (IHC, Human)	IHC	Human
Laura Amo, Javier Díez-García, Estíbaliz Tamayo-Orbegozo, Natalia Maruri, Susana Larrucea Podocalyxin Expressed in Antigen Presenting Cells Promotes Interaction With T Cells and Alters Centrosome Translocation to the Contact Site Frontiers in Immunology 2022-05-31 [PMID: 35711462]
SE Nystrom, G Li, S Datta, K Soldano, D Silas, A Weins, G Hall, DB Thomas, OA Olabisi JAK inhibitor blocks COVID-19-cytokine-induced JAK-STAT-APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids JCI Insight, 2022-06-08;0(0):. 2022-06-08 [PMID: 35472001] (IHC, Human)	IHC	Human
Gupta N, Matsumoto T, Hiratsuka K et al. Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair Science Translational Medicine 2022-03-02 [PMID: 35235339]
Ethan A. Winkler, Chang N. Kim, Jayden M. Ross, Joseph H. Garcia, Eugene Gil, Irene Oh et al. A single-cell atlas of the normal and malformed human brain vasculature Science 2022-03-04 [PMID: 35084939]
L Helms, S Marchiano, IB Stanaway, TY Hsiang, BA Juliar, S Saini, YT Zhao, A Khanna, R Menon, F Alakwaa, C Mikacenic, ED Morrell, MM Wurfel, M Kretzler, JL Harder, CE Murry, J Himmelfarb, H Ruohola-Ba, PK Bhatraju, M Gale, BS Freedman Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations JCI Insight, 2021-12-22;0(0):. 2021-12-22 [PMID: 34767537] (IHC, Human)	IHC	Human
JOR Hernandez, X Wang, M Vazquez-Se, M Lopez-Marf, MF Sobral-Rey, A Moran-Horo, M Sundberg, DO Lopez-Cant, CK Probst, GU Ruiz-Espar, K Giannikou, R Abdi, EP Henske, DJ Kwiatkowsk, M Sahin, DR Lemos A tissue-bioengineering strategy for modeling rare human kidney diseases in vivo Nature Communications, 2021-11-11;12(1):6496. 2021-11-11 [PMID: 34764250] (IHC, Human)	IHC	Human
Ashwani Kumar Gupta, David Z. Ivancic, Bilal A. Naved, Jason A. Wertheim, Leif Oxburgh An efficient method to generate kidney organoids at the air-liquid interface Journal of Biological Methods 2021-06-30 [PMID: 34258308]
Delayna Paulson, Rebecca Harms, Cody Ward, Mackenzie Latterell, Gregory J. Pazour, Darci M. Fink Loss of Primary Cilia Protein IFT20 Dysregulates Lymphatic Vessel Patterning in Development and Inflammation Frontiers in Cell and Developmental Biology 2021-05-14 [PMID: 34055805]
Chen Y, Tristan CA, Lu C et al. A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells Nat Methods 5/4/2021 [PMID: 33941937]
Sachiko Sekiya, Tetsutaro Kikuchi, Tatsuya Shimizu Perfusion culture maintained with an air-liquid interface to stimulate epithelial cell organization in renal organoids in vitro BMC Biomedical Engineering 2019-12-01 [PMID: 32903332]
S Ettou, YL Jung, T Miyoshi, D Jain, K Hiratsuka, V Schumacher, ME Taglienti, R Morizane, PJ Park, JA Kreidberg Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injury Sci Adv, 2020-07-24;6(30):eabb5460. 2020-07-24 [PMID: 32754639] (IHC, Human)	IHC	Human
Kumar Gupta A, Sarkar P, Wertheim J, Pan X, Carroll T, Oxburgh L Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids. Commun Biol, 2020-05-11;3(1):231. 2020-05-11 [PMID: 32393756] (IHC, Mouse)	IHC	Mouse
AI Yu, L Zhao, KA Eaton, S Ho, J Chen, S Poe, J Becker, A Gonzalez, D McKinstry, M Hasso, J Mendoza-Ca, J Whitfield, C Koumpouras, PD Schloss, EC Martens, GY Chen Gut Microbiota Modulate CD8�T Cell Responses to Influence Colitis-Associated Tumorigenesis Cell Rep, 2020-04-07;31(1):107471. 2020-04-07 [PMID: 32268087] (ICC, Human)	ICC	Human
Santelli A, Sun I, Eirin A, Abumoawad A, Woollard J, Lerman A, Textor S, Puranik A, Lerman L Senescent Kidney Cells in Hypertensive Patients Release Urinary Extracellular Vesicles. J Am Heart Assoc, 2019-06-01;8(11):e012584. 2019-06-01 [PMID: 31433703] (ICC, Human)	ICC	Human
JH Low, P Li, EGY Chew, B Zhou, K Suzuki, T Zhang, MM Lian, M Liu, E Aizawa, C Rodriguez, KSM Yong, Q Chen, JM Campistol, M Fang, CC Khor, JN Foo, JC Izpisua Be, Y Xia Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network Cell Stem Cell, 2019-07-11;0(0):. 7/11/2019 [PMID: 31303547]
M Hochane, PR van den Be, X Fan, N Bérenger-C, E Adegeest, M Bialecka, M Nieveen, M Menschaart, SM Chuva de S, S Semrau Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development PLoS Biol., 2019-02-21;17(2):e3000152. 2019-02-21 [PMID: 30789893] (IHC-P, Human)	IHC-P	Human
JL Harder, R Menon, EA Otto, J Zhou, S Eddy, NL Wys, C O'Connor, J Luo, V Nair, C Cebrian, JR Spence, M Bitzer, OG Troyanskay, JB Hodgin, RC Wiggins, BS Freedman, M Kretzler Organoid single cell profiling identifies a transcriptional signature of glomerular disease JCI Insight, 2019-01-10;4(1):. 2019-01-10 [PMID: 30626756] (IHC-P, Human)	IHC-P	Human
Bajaj P, Rodrigues A, Steppan C, Engle S, Mathialagan S, Schroeter T Human Pluripotent Stem Cell-Derived Kidney Model for Nephrotoxicity Studies. Drug Metab Dispos, 2018-08-31;46(11):1703-1711. 2018-08-31 [PMID: 30171163] (ICC, Human)	ICC	Human
S Itai, T Ohishi, MK Kaneko, S Yamada, S Abe, T Nakamura, M Yanaka, YW Chang, SI Ohba, Y Nishioka, M Kawada, H Harada, Y Kato Anti-podocalyxin antibody exerts antitumor effects via antibody-dependent cellular cytotoxicity in mouse xenograft models of oral squamous cell carcinoma Oncotarget, 2018-04-27;9(32):22480-22497. 2018-04-27 [PMID: 29854293] (Flow Cytometry, Human)	Flow Cytometry	Human
S Saito, K Hiemori, K Kiyoi, H Tateno Glycome analysis of extracellular vesicles derived from human induced pluripotent stem cells using lectin microarray Sci Rep, 2018-03-05;8(1):3997. 2018-03-05 [PMID: 29507392] (Flow Cytometry, Western Blot, Human)	Flow Cytometry, Western Blot	Human
J Müller-Dei, P Schröder, L Beverly-St, R Hiss, J Fiedler, J Nyström, T Thum, H Haller, M Schiffer Overexpression of preeclampsia induced microRNA-26a-5p leads to proteinuria in zebrafish Sci Rep, 2018-02-26;8(1):3621. 2018-02-26 [PMID: 29483572] (ICC, Human)	ICC	Human
HG Kang, M Lee, KB Lee, M Hughes, BS Kwon, S Lee, KM McNagny, YH Ahn, JM Ko, IS Ha, M Choi, HI Cheong Loss of podocalyxin causes a novel syndromic type of congenital nephrotic syndrome Exp. Mol. Med., 2017-12-15;49(12):e414. 2017-12-15 [PMID: 29244787] (IHC, Human)	IHC	Human
Yusuke Kaku, Atsuhiro Taguchi, Shunsuke Tanigawa, Fahim Haque, Tetsushi Sakuma, Takashi Yamamoto et al. PAX2 is dispensable for in vitro nephron formation from human induced pluripotent stem cells Scientific Reports 2017-07-03 [PMID: 28674456]
LD Volk-Drape, KL Hall, AC Wilber, S Ran Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4 PLoS ONE, 2017-06-09;12(6):e0179257. 2017-06-09 [PMID: 28598999] (ICC, Human)	ICC	Human
Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells Nat Protoc, 2016-12-22;12(1):195-207. 2016-12-22 [PMID: 28005067] (IHC, Human)	IHC	Human
?-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function J Neurosci, 2016-08-24;36(34):8921-35. 2016-08-24 [PMID: 27559173] (IHC-Fr, IHC-P, Mouse)	IHC-Fr, IHC-P	Mouse
VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation Mol Biol Cell, 2016-07-27;0(0):. 7/27/2016 [PMID: 27466317]
Sharmin S, Taguchi A, Kaku Y et al. Human Induced Pluripotent Stem Cell-Derived Podocytes Mature into Vascularized Glomeruli upon Experimental Transplantation. J. Am. Soc. Nephrol. 11/19/2015 [PMID: 26586691]
Sabu Abraham, Margherita Scarcia, Richard D. Bagshaw, Kathryn McMahon, Gary Grant, Tracey Harvey et al. A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis Nature Communications 2015-07-01 [PMID: 26129894]
Ylostalo J, Bazhanov N, Prockop DJ Reversible commitment to differentiation by human multipotent stromal cells in single-cell-derived colonies. Exp. Hematol., 2008-07-10;36(10):1390-402. 2008-07-10 [PMID: 18619725] (ICC, Human)	ICC	Human
Show All 37 Publications. Collapse Publications.

Array AF1658

• Podocalyxin Like Antibodies
• Podocalyxin Like ELISA Kits
• Podocalyxin Like Lysate
• Podocalyxin Like Proteins
• Podocalyxin Like Proteins and Enzymes