FoxC1 Antibody

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 6 applications: Chemotaxis, ICC/IF, IHC-Fr, IHC-P, KO, WB.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using NB100-1268	Applications	Species
Lee YH, Lee HT, Chen CL et al. Role of FOXC1 in regulating APSCs self-renewal via STI-1/PrPC signaling. Theranostics. 2019-08-15 [PMID: 31588228] (ICC/IF, Chemotaxis, WB, KO, Mouse)	ICC/IF, Chemotaxis, WB, KO	Mouse
Hirukawa A, Smith HW, Zuo D et al. Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program. Nat Commun. 2018-06-29 [PMID: 29959321] (IHC-P, Mouse)	IHC-P	Mouse
Lin Yu-Jung, Shyu Woei-Cherng, Chang Chi-Wei et al. Tumor Hypoxia Regulates Forkhead Box C1 to Promote Lung Cancer Progression. Theranostics 2018-03-05 [PMID: 28435458] (WB, IHC-Fr, Human)	WB, IHC-Fr	Human
Wang X, Shan X, Gregory-Evans CY. A mouse model of aniridia reveals the in vivo downstream targets of Pax6 driving iris and ciliary body development in the eye. Biochim. Biophys. Acta 2016-10-20 [PMID: 27771509] (IHC-P)	IHC-P
Wang J, Xiao Y, Hsu CW et al. Yap and Taz play a crucial role in neural crest-derived craniofacial development. Development. 2016-02-01 [PMID: 26718006] (IHC-P, Mouse)	IHC-P	Mouse
Siegenthaler JA, Choe Y, Patterson KP et al. Foxc1 is required by pericytes during fetal brain angiogenesis. Biol Open 2013-05-20 [PMID: 23862012] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Hayashi H, Kume T. Foxc transcription factors directly regulate Dll4 and Hey2 expression by interacting with the VEGF-Notch signaling pathways in endothelial cells. PLoS One 11;3(6):e2401. 2008-06-01 [PMID: 18545664]
Berry FB, Skarie JM, Mirzayans F, Fortin Y, Hudson TJ, Raymond V, Link BA, Walter MA. FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A. Hum Mol Genet15;17(4):490-505. 2008-02-01 [PMID: 17993506]
Zarbalis, K et al. Cortical dysplasia skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development. PNAS, Aug; 104: 14002 - 14007. 2007-01-01 [PMID: 17715063]
Tamimi Y, Skarie JM, Footz T, Berry FB, Link BA, Walter MA. FGF19 is a target for FOXC1 regulation in ciliary body-derived cells. um Mol Genet 1;15(21):3229-40. 2006-11-01 [PMID: 17000708]
Berry FB, Lines MA, Oas JM, Footz T, Underhill DA, Gage PJ, Walter MA. Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis. Hum Mol Genet15;15(6):905-19. 2006-03-01 [PMID: 16449236]
Zhou Y, Kato H, Asanoma K et al. Identification of FOXC1 as a TGF-beta1 responsive gene and its involvement in negative regulation of cell growth. Genomics 2002-11-01 [PMID: 12408963]
Show All 12 Publications. Collapse Publications.

Array NB100-1268

• FoxC1 Antibodies
• FoxC1 Lysate
• FoxC1 Protein