PIR-B Antibody (326414)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Mouse PIR-B is a 125 kDa type I transmembrane glycoprotein with six Ig-like domains in its extracellular domain (ECD) and four ITIM-like sequences in its cytoplasmic domain. The ECD of PIR-B is highly homologous to the ECDs of multiple mouse PIR-A receptors (92-99% amino acid sequence homology), which have short cytoplasmic tails lacking ITIM motifs. PIR-A receptors have a charged residue in their transmembrane domain that facilitates interaction with ITAM-containing adaptor molecules. Whereas PIR-A receptors deliver activation signals, PIR-B can inhibit receptor-mediated activation signaling. PIR-A and PIR-B have been shown to bind various mouse MHC class I molecules. They have been proposed to be orthologs of human leukocyte immunoglobulin-like receptors.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Flow Cytometry, IHC-Fr.

Showing Publications 1 - 6 of 6.

Publications using MAB2754	Applications	Species
Peitao Wu, Yuhang Guo, Li Xiao, Jiaqi Yuan, Chao Tang, Jun Dong et al. LILRB2-containing small extracellular vesicles from glioblastoma promote tumor progression by promoting the formation and expansion of myeloid-derived suppressor cells Cancer Immunology, Immunotherapy 2023-07-01 [PMID: 36853330]
Jamie J. Kwan, Sladjana Slavkovic, Michael Piazza, Dingyan Wang, Thorsten Dieckmann, Philip E. Johnson et al. HACS1 signaling adaptor protein recognizes a motif in the paired immunoglobulin receptor B cytoplasmic domain Communications Biology 2020-11-13 [PMID: 33188360]
An H, Brettle M, Lee T et al. Soluble LILRA3 promotes neurite outgrowth and synapses formation through high affinity interaction with Nogo 66. J Cell Sci 1/29/2016 [PMID: 26826187]
Williams , Jesse W, Tjota , Melissa, Clay , Bryan S, Vander Lugt , Bryan, Bandukwala , Hozefa S, Hrusch , Cara L, Decker , Donna C, Blaine , Kelly M, Fixsen , Bethany, Singh , Harinder, Sciammas , Roger, Sperling , Anne I Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation. Nat Commun, 2013-01-01;4(0):2990. 2013-01-01 [PMID: 24356538] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Verjan Garcia N, Umemoto E, Saito Y, Yamasaki M, Hata E, Matozaki T, Murakami M, Jung YJ, Woo SY, Seoh JY, Jang MH, Aozasa K, Miyasaka M SIRP{alpha}/CD172a Regulates Eosinophil Homeostasis. J. Immunol., 2011-07-20;187(5):2268-77. 2011-07-20 [PMID: 21775684] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Thams S, Brodin P, Plantman S, Saxelin R, Karre K, Cullheim S Classical major histocompatibility complex class I molecules in motoneurons: new actors at the neuromuscular junction. J. Neurosci., 2009-10-28;29(43):13503-15. 2009-10-28 [PMID: 19864563] (Flow Cytometry, IHC-Fr, Mouse)	Flow Cytometry, IHC-Fr	Mouse

Array MAB2754

• PIR-B Antibodies
• PIR-B Proteins and Enzyme