Orthogonal Strategies: Immunohistochemistry-Paraffin: Periaxin Antibody [NBP1-89598] - Analysis in human lung and liver tissues. Corresponding PRX RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Periaxin Antibody [NBP1-89598] - Staining of human lung shows strong membranous positivity in pneumocytes.
Immunohistochemistry-Frozen: Periaxin Antibody [NBP1-89598] - Staining of Periaxin in mouse sciatic nerve using anti-Periaxin antibody (green). Image from verified customer review.
Immunohistochemistry-Paraffin: Periaxin Antibody [NBP1-89598] - Staining of human kidney shows strong membranous positivity in cells in glomeruli.
Immunohistochemistry-Paraffin: Periaxin Antibody [NBP1-89598] - Staining of human liver shows no positivity in hepatocytes as expected.
Immunohistochemistry-Paraffin: Periaxin Antibody [NBP1-89598] - Staining of human testis shows no positivity in cells in seminiferous ducts as expected.
This antibody was developed against Recombinant Protein corresponding to amino acids: MKVPDMKLPEIKLPKVPEMAVPDVHLPEVQLPKVSEIRLPEMQVPKVPDVHLPKAPEVKLPRAPEVQLKATKAEQAEGMEFGFKMPKMTMPKLGRAESPSRGKPGEAGAEVSGKLVTLPCLQPEVDGEAHVGVPSLTLPSVELDL
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PRX
Purity
Immunogen affinity purified
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Canine reactivity reported in scientific literature (PMID: 26196511). Mouse reactivity reported from a verified customer review.
Packaging, Storage & Formulations
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for Periaxin Antibody
CMT4F
PRX
Background
Periaxin is involved in peripheral nerve myelin upkeep. The encoded protein contains 2 PDZ domains which were named after PSD95 (post synaptic density protein), DlgA (Drosophila disc large tumor suppressor), and ZO1 (a mammalian tight junction protein). Two alternatively spliced transcript variants have been described for this gene which encode different protein isoforms and which are targeted differently in the Schwann cell. Mutations in this gene cause Charcot-Marie-Tooth neuoropathy, type 4F and Dejerine-Sottas neuropathy. [provided by RefSeq, Jul 2008]
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for Periaxin Antibody (NBP1-89598). (Showing 1 - 1 of 1 FAQs).
Could you tell me if you expect the periaxin antibody NBP1-89598 to react with rat tissue?
This antibody has not been tested in rat. I performed a blast homology comparison to Rat with the immunogen and found only a 69% homology. However this has been validated in Mouse and Mouse only has a 72% homology and it seems to work fine. Mouse and rat are 92% homologous. The problem is that we cannot guarantee the antibody will work in rat but we can presume it will. This antibody was developed against Recombinant Protein corresponding to amino acids: MKVPDMKLPEIKLPKVPEMAVPDVHLPEVQLPKVSEIRLPEMQVPKVPDVHLPKAPEVKLPRAPEVQLKATKAEQAEGMEFGFKMPKMTMPKLGRAESPSRGKPGEAGAEVSGKLVTLPCLQPEVDGEAHVGVPSLTLPSVELDL
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