PAR1/Thrombin Receptor Antibody (N2-11) [DyLight 650]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Thrombin Receptor, also known as Protease activated receptor 1 (PAR1), is a G-protein-coupled receptor that is highly expressed in invasive cancers. While Thrombin Receptor is known to have important functions in wound healing, by inducing human platelet recruitment to form stable blood clots for vascular injury, its misregulation seems to be intrinsically linked to the formation of invasive and deadly cancers. Thrombin Receptor is important in the cell invasion of cutaneous malignant melanoma, along with its partner KLK6. In lung cancer, Thrombin Receptor migration pairs with ERK1/2 activity to induce cell migration and tumor growth. Thrombin Receptor is known to interact with FAK, which alters endothelial barriers which normally would inhibit cell proliferation across boundaries. It is probably through this relationship that many metastatic effects associated with Thrombin Receptor are compounded. Thrombin Receptor normally functions to assist with healing, particularly in vasculature, but when it is not appropriately regulated, it can catalyze cancer growth and metastasis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP1-71770C

• PAR1/Thrombin Receptor Antibodies
• PAR1/Thrombin Receptor ELISA Kit
• PAR1/Thrombin Receptor Lysate
• PAR1/Thrombin Receptor Proteins