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Recombinant Human p18INK4c/CDKN2C His Protein

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SDS-Page: Recombinant Human p18INK4c/CDKN2C Protein [NBP1-78876] - 15% SDS-PAGE (3ug)

Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE
Concentration
0.5 mg/ml

Order Details

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Recombinant Human p18INK4c/CDKN2C His Protein Summary

Description
A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-168 of Human p18INK4c/CDKN2C

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMAEPWG NELASAAARG DLEQLTSLLQ NNVNVNAQNG FGRTALQVMK LGNPEIARRL LLRGANPDLK DRTGFAVIHD AARAGFLDTL QTLLEFQADV NIEDNEGNLP LHLAAKEGHL RVVEFLVKHT ASNVGHRNHK GDTACDLARL YGRNEVVSLM QANGAGGATN LQ

Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
CDKN2C
Purity
>95%, by SDS-PAGE

Applications/Dilutions

Dilutions
  • SDS-Page
Theoretical MW
20.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20 mM Tris-HCl buffer (pH 8.0), 2 mM DTT, 10% glycerol, 200 mM NaCl
Preservative
No Preservative
Concentration
0.5 mg/ml
Purity
>95%, by SDS-PAGE

Alternate Names for Recombinant Human p18INK4c/CDKN2C His Protein

  • CDK6 inhibitor p18
  • CDKN2C
  • CDKN6
  • cyclin-dependent inhibitor
  • cyclin-dependent kinase 4 inhibitor C
  • Cyclin-dependent kinase 6 inhibitor
  • cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
  • INK4Ccyclin-dependent kinase 6 inhibitor p18
  • p18
  • p18INK4c
  • p18-INK4C
  • p18-INK6

Background

CDKN2C (Cyclin-dependent kinase 4 inhibitor C ) belongs to the CDKN2 cyclin-dependent kinase inhibitor family. It has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. And this protein suppresses the cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Recombinant human CDKN2C protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol CDKN2C