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p16INK4a/CDKN2A Antibody (CDKN2A/4844R) [Janelia Fluor® 635]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clone
CDKN2A/4844R
Clonality
Monoclonal
Host
Rabbit
Conjugate
Janelia Fluor 635

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-14223AF350
Alexa Fluor 405
NBP3-14223AF405
Alexa Fluor 488
NBP3-14223AF488
Alexa Fluor 532
NBP3-14223AF532
Alexa Fluor 594
NBP3-14223AF594
Alexa Fluor 647
NBP3-14223AF647
Alexa Fluor 700
NBP3-14223AF700
Alexa Fluor 750
NBP3-14223AF750
Allophycocyanin
NBP3-14223APC
Biotin
NBP3-14223B
CoraFluor 1
NBP3-14223CL1
DyLight 350
NBP3-14223UV
DyLight 405
NBP3-14223V
DyLight 488
NBP3-14223G
DyLight 550
NBP3-14223R
DyLight 594
NBP3-14223DL594
DyLight 650
NBP3-14223C
DyLight 680
NBP3-14223FR
DyLight 755
NBP3-14223IR
FITC
NBP3-14223F
HRP
NBP3-14223H
Janelia Fluor 525
NBP3-14223JF525
Janelia Fluor 549
NBP3-14223JF549
Janelia Fluor 585
NBP3-14223JF585
Janelia Fluor 646
NBP3-14223JF646
Janelia Fluor 669
NBP3-14223JF669
PE
NBP3-14223PE
PerCP
NBP3-14223PCP
Unconjugated
NBP3-13833-100ug
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP3-13833-100ug
Azide and BSA Free
NBP3-14223
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p16INK4a/CDKN2A Antibody (CDKN2A/4844R) [Janelia Fluor® 635] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
Recombinant full-length human p16INK4a protein (Uniprot: P42771)
Localization
Nucleus, Cytoplasm
Isotype
IgG Kappa
Clonality
Monoclonal
Host
Rabbit
Gene
CDKN2A
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for p16INK4a/CDKN2A Antibody (CDKN2A/4844R) [Janelia Fluor® 635]

  • ARF
  • CDK4 inhibitor p16-INK4
  • CDK4I
  • CDK4IP14ARF
  • CDKN2
  • CDKN2A
  • cell cycle negative regulator beta
  • CMM2P16-INK4A
  • Cyclin-dependent kinase 4 inhibitor A
  • cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
  • cyclin-dependent kinase inhibitor 2A
  • INK4
  • INK4a
  • MLM
  • MLMP16INK4
  • MTS-1
  • MTS1P14
  • Multiple tumor suppressor 1
  • p14
  • p14ARF
  • p16
  • p16-INK4
  • p16INK4a
  • p16-INK4a
  • P19
  • p19ARF
  • TP16

Background

CDKN2A/p16INK4a is a gene that codes for a widely expressed protein with four isoforms, measuring 156, 105, 116, and 167 amino acids in length with weights of approximately 17, 11, 12, and 18 kDa respectively. CDKN2A/p16INK4a functions as a negative regulator of the proliferation of cells, which then allows them to interact with cyclins D and to phosphorylate the retinoblastoma protein. Current studies are being done on several diseases and disorders related to this gene including Li-Fraumeni syndrome, malignant peripheral nerve sheath tumor, blastic plasmacytoid dendritic cell, acth-secreting pituitary adenoma, recessive dystrophic epidermolysis bullosa, marginal zone b-cell lymphoma, adult astrocytic tumor, melanoma, and squamous cell carcinoma. CDKN2A/p16INK4a has also been shown to have interactions with MDM2, ZNF420, EGR1, MYCN, and CDK6 in pathways such as the cell cycle, p53 signaling, mitochondrial apoptosis, HIF-1 Alpha, CRHR, pancreatic cancer, and glioma pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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p16INK4a/CDKN2A
Antibody (CDKN2A/4844 ...
NBP3-14223JF635
p16INK4a/CDKN2A Antibody (CDKN2A/4844R) [Janelia Fluor® 635]
Species: Hu
Applications: WB, IHC

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Product General Protocols

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FAQs for p16INK4a/CDKN2A Antibody (NBP3-14223JF635). (Showing 1 - 1 of 1 FAQ).

  1. Our customer asked us about NBP1-02905, which we lately found it discontinued. While checking its related products, there seems none. Would you please help confirm if there is any replacement available?
    • With regards to your question on our CDKN2A antibodies, we do supply a wide range of products, but you haven't specified which application you are referring to. Please go through this link (cyclin-dependent kinase inhibitor 2A) and choose the product that will suit your experiment and the species you are working with. Meanwhile it is important to keep in mind that CDKN2A generates several transcript variants which differ in their first exons.

Secondary Antibodies

 

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Bioinformatics

Gene Symbol CDKN2A