p16INK4a/CDKN2A Products

Description

CDKN2A/p16INK4a is a gene that codes for a widely expressed protein with four isoforms, measuring 156, 105, 116, and 167 amino acids in length with weights of approximately 17, 11, 12, and 18 kDa respectively. CDKN2A/p16INK4a functions as a negative regulator of the proliferation of cells, which then allows them to interact with cyclins D and to phosphorylate the retinoblastoma protein. Current studies are being done on several diseases and disorders related to this gene including Li-Fraumeni syndrome, malignant peripheral nerve sheath tumor, blastic plasmacytoid dendritic cell, acth-secreting pituitary adenoma, recessive dystrophic epidermolysis bullosa, marginal zone b-cell lymphoma, adult astrocytic tumor, melanoma, and squamous cell carcinoma. CDKN2A/p16INK4a has also been shown to have interactions with MDM2, ZNF420, EGR1, MYCN, and CDK6 in pathways such as the cell cycle, p53 signaling, mitochondrial apoptosis, HIF-1 Alpha, CRHR, pancreatic cancer, and glioma pathways.

Bioinformatics

Uniprot	NM_000077 Human Q8N726 Human
Product By Gene ID	1029
Alternate Names	ARF CDK4 inhibitor p16-INK4 CDK4IP14ARF CDKN2 cell cycle negative regulator beta CMM2P16-INK4A Cyclin-dependent kinase 4 inhibitor A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) cyclin-dependent kinase inhibitor 2A INK4 INK4A INK4a MLMP16INK4 MTS-1 MTS1P14 Multiple tumor suppressor 1 p14 p14ARF p16 P16 p16-INK4 p16INK4A p16INK4a P16INK4A p16-INK4a p19 P19 P19ARF p19Arf p19ARF TP16

Research Areas for p16INK4a/CDKN2A

Find related products by research area and learn more about each of the different research areas below.

ABC Transporters
Cancer
Cell Cycle and Replication
DNA Repair
Hypoxia
MAP Kinase Signaling
Neuroscience
Phospho-Specific
Tumor Suppressors