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Numb Antibody [DyLight 755]

 
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Product Details

Summary
Reactivity Hu, Mu, Ch, RtSpecies Glossary
Applications WB, Simple Western, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 755

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB500-178AF350
Alexa Fluor 405
NB500-178AF405
Alexa Fluor 488
NB500-178AF488
Alexa Fluor 532
NB500-178AF532
Alexa Fluor 594
NB500-178AF594
Alexa Fluor 647
NB500-178AF647
Alexa Fluor 700
NB500-178AF700
Alexa Fluor 750
NB500-178AF750
Allophycocyanin
NB500-178APC
Biotin
NB500-178B
CoraFluor 1
NB500-178CL1
DyLight 350
NB500-178UV
DyLight 405
NB500-178V
DyLight 488
NB500-178G
DyLight 550
NB500-178R
DyLight 594
NB500-178DL594
DyLight 650
NB500-178C
DyLight 680
NB500-178FR
FITC
NB500-178F
HRP
NB500-178H
Janelia Fluor 525
NB500-178JF525
Janelia Fluor 549
NB500-178JF549
Janelia Fluor 585
NB500-178JF585
Janelia Fluor 635
NB500-178JF635
Janelia Fluor 646
NB500-178JF646
Janelia Fluor 669
NB500-178JF669
PE
NB500-178PE
PerCP
NB500-178PCP
Unconjugated
NB500-178
mFluor Violet 450 SE
NB500-178MFV450
mFluor Violet 500 SE
NB500-178MFV500
mFluor Violet 610 SE
NB500-178MFV610
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Numb Antibody [DyLight 755] Summary

Immunogen
A synthetic peptide made to a C-terminal region of mouse NUMB (between residues 600-653). [UniProt# Q9QZS3]
Localization
Membrane-associated
Specificity
This is specific for all four isoforms of the NUMB protein.
Predicted Species
Rat (90%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NUMB
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Simple Western
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Immunogen sequence has 90% identity to rat.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Numb Antibody [DyLight 755]

  • h-Numb
  • mnb
  • m-numb
  • numb (Drosophila) homolog
  • numb homolog (Drosophila)
  • Numb
  • protein numb homolog
  • Protein S171
  • S171

Background

Numb is a transmembrane signaling receptor that is activated by the DSL family of ligands. Studies suggestthat mammalian Numb plays a role in progenitor cell fate in neurogenesis. Numb exerts its role on cell fate by antagonizing Notch signaling. The mammalian Numb gene undergoes alternative splicing to produce at least four functionally different Numb isoforms which regulate different processes. A loss of Numb expression has been demonstrated in breast cancer, non-small cell lung cancer and chronic myelogenous leukemia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Western Blot PTBP1 Antibody (3H8)
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Numb Antibody
[DyLight 755]
NB500-178IR
Numb Antibody [DyLight 755]
Species: Hu, Mu, Ch, Rt
Applications: WB, Simple Western, ICC/IF

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol NUMB