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NMNAT3 Antibody

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Immunohistochemistry-Paraffin: NMNAT3 Antibody [NBP2-31675] - Staining of human kidney shows strong cytoplasmic positivity in renal tubules.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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NMNAT3 Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: VDPWESEQAQWMETVKVLRHHHSKLLRSPPQMEGPDHGKALFSTPAAVPELKLLCGADVLKTFQTPNLWKDAHIQEIVEKFGLVCV
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NMNAT3
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:1000 - 1:2500
  • Immunohistochemistry-Paraffin 1:1000 - 1:2500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
NMNAT3 Protein (NBP2-31675PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (84%), Rat (83%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for NMNAT3 Antibody

  • EC 2.7.7.1
  • EC 2.7.7.18
  • NaMN adenylyltransferase 3
  • nicotinamide mononucleotide adenylyltransferase 3
  • nicotinamide nucleotide adenylyltransferase 3
  • Nicotinate-nucleotide adenylyltransferase 3
  • PNAT-3
  • PNAT3NMN adenylyltransferase 3
  • Pyridine nucleotide adenylyltransferase 3

Background

The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD (Zhang et al., 2003 [PubMed 12574164]).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol NMNAT3
Uniprot