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Neurofibromin 1 Antibody [Janelia Fluor® 635]

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Product Details

Summary
Reactivity Hu, Mu, Ce, RtSpecies Glossary
Applications WB, ICC/IF, IP, KD
Clonality
Polyclonal
Host
Rabbit
Conjugate
Janelia Fluor 635

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB100-418AF350
Alexa Fluor 405
NB100-418AF405
Alexa Fluor 488
NB100-418AF488
Alexa Fluor 532
NB100-418AF532
Alexa Fluor 594
NB100-418AF594
Alexa Fluor 647
NB100-418AF647
Alexa Fluor 700
NB100-418AF700
Alexa Fluor 750
NB100-418AF750
Allophycocyanin
NB100-418APC
Biotin
NB100-418B
CoraFluor 1
NB100-418CL1
DyLight 350
NB100-418UV
DyLight 405
NB100-418V
DyLight 488
NB100-418G
DyLight 550
NB100-418R
DyLight 594
NB100-418DL594
DyLight 650
NB100-418C
DyLight 680
NB100-418FR
DyLight 755
NB100-418IR
FITC
NB100-418F
HRP
NB100-418H
Janelia Fluor 525
NB100-418JF525
Janelia Fluor 549
NB100-418JF549
Janelia Fluor 585
NB100-418JF585
Janelia Fluor 646
NB100-418JF646
Janelia Fluor 669
NB100-418JF669
PE
NB100-418PE
PerCP
NB100-418PCP
Unconjugated
NB100-418
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Neurofibromin 1 Antibody [Janelia Fluor® 635] Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 2760 and the C-terminus (residue 2818) of human Neurofibromin 1 using the numbering given in entry NP_000258.1 (GeneID 4763)
Predicted Species
Rat (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NF1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunoprecipitation
  • Knockdown Validated
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

C. elegans reactivity reported in scientific literature (PMID: 30929290).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Neurofibromin 1 Antibody [Janelia Fluor® 635]

  • DKFZp686J1293
  • FLJ21220
  • Neurofibromatosis-related protein NF-1
  • neurofibromin 1
  • neurofibromin
  • NFNS
  • VRNF
  • WSS

Background

Neurofibromin 1 (NF1) is a suspected negative regulator of the ras signal transduction pathway. Neurofibromin is known to regulate the GTPase HRAS, causing the hydrolyzation and inactivation of GTP. Defects in NF1 lead to Neurofibromatosis disease, Recklinghausen disease or Watson disease. Neurofibromin has not been purified, therefore, most of the information regarding this protein has been deduced from homology analysis of its gene sequence.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Neurofibromin 1 Antibody (NB100-418JF635) (0)

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Secondary Antibodies

 

Isotype Controls

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Check out the latest blog posts on Neurofibromin 1.
Developmental regulator Daam2 promotes glial cell tumors by degrading Von Hippel-Lindau protein
By Jamshed Arslan Pharm.D. Glioblastoma is an aggressive type of cancer that forms from the star-shaped glial cells of the central nervous system, called astrocytes. Intriguingly, several genes linked to glioblasto...  Read full blog post.
Neurofibromatosis Infographic
Neurofibromatosis (NF) is a genetic disorder caused by mutations in the NF1, NF2 or SMARCB1 genes which lead to tumor growth on nerves throughout the body. Although the tumors are usually benign, they still require chemotherapy to shrink and may becom...  Read full blog post.
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Bioinformatics

Gene Symbol NF1