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Napsin A Antibody (CL12954)

Images

 
Immunohistochemistry-Paraffin: Napsin A Antibody (CL12954) [NBP3-18551] - Staining of human cerebral cortex shows no positivity in neurons as expected.
Immunohistochemistry-Paraffin: Napsin A Antibody (CL12954) [NBP3-18551] - Analysis in human kidney and skeletal muscle tissues using NBP3-18551 antibody. Corresponding NAPSA RNA-seq data are presented for the same ...read more
Immunohistochemistry-Paraffin: Napsin A Antibody (CL12954) [NBP3-18551] - Staining of human ovarian cancer (clear cell carcinoma) shows moderate to strong granular cytoplasmic positivity in tumor cells.
Immunohistochemistry-Paraffin: Napsin A Antibody (CL12954) [NBP3-18551] - Staining of human lung cancer (adenocarcinoma) shows moderate to strong positivity in tumor cells.
Immunohistochemistry-Paraffin: Napsin A Antibody (CL12954) [NBP3-18551] - Staining of human kidney shows moderate to strong cytoplasmic positivity in cells in tubules.
Immunohistochemistry-Paraffin: Napsin A Antibody (CL12954) [NBP3-18551] - Staining of human skeletal muscle shows no positivity in myocytes as expected.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
CL12954
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

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Napsin A Antibody (CL12954) Summary

Immunogen
This antibody was developed against a sythetic peptide for O96009. Actual immunogen sequence is proprietary.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
NAPSA
Purity
Protein A purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:5000 - 1:10000
  • Immunohistochemistry-Paraffin 1:5000 - 1:10000
Application Notes
For use with IHC-Paraffin, HIER pH 6 retrieval is recommended.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, pH 7.2, 40% glycerol
Preservative
0.02% Sodium Azide
Purity
Protein A purified

Alternate Names for Napsin A Antibody (CL12954)

  • Asp 4
  • ASP4
  • Aspartyl protease 4
  • EC 3.4.23
  • EC 3.4.23.-
  • EC 3.4.23.15
  • EC 3.4.23.3
  • EC 3.4.23.5
  • KAP
  • Kdap
  • NAP1napsin-A
  • NAPA
  • NAPApronapsin A
  • NAPSA
  • napsin A aspartic peptidase
  • Napsin A
  • Napsin-1
  • SNAPA
  • TA01/TA02

Background

Napsin is a pepsin-like aspartic proteinase, in the A1 clan of the AA clade of proteinases. Other AA family proteinases include Pepsin, cathepsin-D, cathepsin-E and rennin. Of these proteinases, napsin is most closely related to cathepsin-D, sharing 46% identity at the amino acid level. There are two closely related Napsins, napsin A and napsin B, with 85% overall identity at the amino acid level. There are three isoforms. Napsin-A is also termed napsin-1, or TA02, a Tumor Adenocarcinoma marker. Napsin A may be involved in processing of pneumocyte surfactant precursors.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol NAPSA