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mu Opioid R/OPRM1 Antibody (1126B) [Unconjugated]

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μ Opioid R/OPRM1 was detected in perfusion fixed frozen sections of rat spinal cord using Rabbit Anti-Ratμ Opioid R/OPRM1 Monoclonal Antibody (Catalog # MAB8629) at 1 μg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Rabbit IgG Secondary Antibody (red; Catalog # NL004) and counterstained with DAPI (blue). Specific staining was localized to dorsal horn. View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.
μ Opioid R/OPRM1 was detected in perfusion fixed frozen sections of rat spinal cord using Rabbit Anti-Ratμ Opioid R/OPRM1 Monoclonal Antibody (Catalog # MAB8629) at 1 μg/mL overnight at 4 °C. Tissue was stained ...read more

Product Details

Summary
Reactivity RtSpecies Glossary
Applications IHC
Clone
1126B
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB8629-SP
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mu Opioid R/OPRM1 Antibody (1126B) [Unconjugated] Summary

Additional Information
Recombinant Monoclonal Antibody.
Immunogen
Synthetic peptide with a short amino acid sequence from the N-terminus of rat μ Opioid R/OPRM1
Accession # P33535
Specificity
Detects rat μ Opioid R/OPRM1 in direct ELISAs.
Source
N/A
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
OPRM1
Purity Statement
Protein A or G purified from cell culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1-25 ug/mL
Publications
Read Publications using
MAB8629 in the following applications:

  • ICC
    1 publication

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
Sodium Azide
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for mu Opioid R/OPRM1 Antibody (1126B) [Unconjugated]

  • hMOP
  • KIAA0403
  • LMOR
  • MOP
  • mOpioidR
  • MOR
  • MOR1
  • M-OR-1
  • MOR-1
  • MOR1MOR
  • Mu opiate receptor
  • mu Opioid R
  • Mu opioid receptor
  • mu-type opioid receptor
  • opioid receptor, mu 1
  • OPRM
  • OPRM1

Background

The mu-type opioid receptor (MOR), also known as OPRM1, is a 60‑70 kDa variably glycosylated G protein-coupled receptor that mediates the biological effects of many alkaloid and peptide opioids including morphine. MOR is primarily expressed on neurons in the brain, spinal cord, and gastrointestinal tract as well as on immune cells. MOR activation induces analgesia, euphoria, sedation, respiratory depression, and reduced intestinal motility. Following agonist binding, MOR is phosphorylated and internalized which contributes to opioid tolerance and desensitization. OPRM1 can form heterdimers with several other 7TM GPCRs including the delta-type Opioid Receptor (DOR), Nociceptin/Orphanin Receptor (ORL1), Neurokinin 1 Receptor (NK1), Somatostatin Receptor 2 (SSTR2), Cannabinoid Receptor 1, CCR5, and the alpha 2A-Adrenergic Receptor (ADRA2A). Rat MOR shares 94% and 98% aa sequence identity with human and mouse MOR, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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mu Opioid R/OPRM1
Antibody (1126B) [Unc ...
MAB8629
mu Opioid R/OPRM1 Antibody (1126B) [Unconjugated]
Species: Rt
Applications: IHC

Publications for mu Opioid R/OPRM1 Antibody (MAB8629)(2)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: ICC.


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Bioinformatics

Gene Symbol OPRM1
Uniprot