Mouse LDLR DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

LDL R (Low Density Lipoprotein Receptor) is a widely expressed cell surface scavenger receptor. LDL R binds ApoB and ApoE, the apolipoproteins of low- and very low-density lipoproteins (LDL and VLDL), respectively. Hepatocyte LDL R is responsible for endocytosis and clearing of most plasma LDL cholesterol. At the low pH of the endocytic vesicle, it dissociates, allowing degradation of LDL and recycling of LDL R to the cell surface. Lack of LDL R expression or function causes familial hypercholesterolemia (FH). The protease PCSK9 can also cause increased plasma cholesterol by promoting LDL R degradation rather than recycling to the cell surface.

We have publications tested in 1 confirmed species: Mouse.

Showing Publication 1 - 1 of 1.

Publication using DY2255	Applications	Species
A Alabi, XD Xia, HM Gu, F Wang, SJ Deng, N Yang, A Adijiang, DN Douglas, NM Kneteman, Y Xue, L Chen, S Qin, G Wang, DW Zhang Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis Nature Communications, 2021-03-25;12(1):1889. 2021-03-25 [PMID: 33767172] (Mouse)		Mouse

Array DY2255

• LDLR Antibodies
• LDLR Antibody Pair
• LDLR ELISA Kit
• LDLR Lysate
• LDLR Proteins
• LDLR ELISAs
• LDLR Proteins and Enzymes