Immunohistochemistry-Paraffin: mGluR1 Antibody [NLS882] - Anti-GRM1 / MGLUR1 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen ...read more
Immunohistochemistry-Paraffin: mGluR1 Antibody [NLS882] - Anti-GRM1 / MGLUR1 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen ...read more
Immunohistochemistry-Paraffin: mGluR1 Antibody [NLS882] - Anti-GRM1 / MGLUR1 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Predicted cross-reactivity based on sequence identity: Rabbit (81%).
Packaging, Storage & Formulations
Storage
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified
Alternate Names for mGluR1 Antibody - BSA Free
glutamate receptor, metabotropic 1
GPRC1A
GRM1
GRM1A
metabotropic glutamate receptor 1
mGluR1
MGLUR1A
MGLUR1GPRC1AmGlu1
Background
The Metabotropic Glutamate Receptor mGluR1 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. mGluR1 and mGluR5 are group I receptors that have been shown to activate phospholipase C. Alternative splice variants of the mGluR1 gene have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signalregulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
We have publications tested in 1 confirmed species: Human.
We have publications tested in 1 application: IHC-P.
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Publication using NLS882
Applications
Species
Hirata E, Ishibashi K, Ichinose T et al. Brain mimetic co-culture experiments identify mGluR1 dependence as a vulnerability of lung cancer brain metastasis Research Square 2023-05-11 (IHC-P, Human)
IHC-P
Human
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