mGluR1 Antibody

The Metabotropic Glutamate Receptor mGluR1 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. mGluR1 and mGluR5 are group I receptors that have been shown to activate phospholipase C. Alternative splice variants of the mGluR1 gene have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. mGluR1 has been reported in various regions of the brain and spinal cord. ESTs have been isolated from brain and eye libraries. Caution: GLUR1 refers to Ionotropic Glutamate Receptor 1, not to Metabotropic Glutamate Receptor 1 (mGLUR1).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 2 of 2.

Publications using NB300-123	Applications	Species
Musante I, Mattinzoli D, Otescu LA et al. Phenotypic characterization of Grm1(crv4) mice reveals a functional role for the type 1 metabotropic glutamate receptor in bone mineralization Bone 2017-01-01 [PMID: 27989650]
Li M, Corbelli A, Watanabe S et al. Three-Dimensional Podocyte-Endothelial Cell Co-cultures: Assembly, Validation, and Application to Drug Testing and Intercellular Signaling Studies Eur J Pharm Sci 2016-02-23 [PMID: 26924225] (ICC/IF, WB, Mouse)	ICC/IF, WB	Mouse

Array NB300-123

• mGluR1 Antibodies
• mGluR1 Lysate
• mGluR1 Proteins