Mesothelin Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Mesothelin is a 40 kDa, 292 amino acid (aa) GPI-linked glycoprotein found on normal mesothelial cells. It is also highly expressed in pancreatic, gastric and ovarian carcinomas. Mesothelin is synthesized as a preproprotein with a carboxy-terminal hydrophobic proregion that is removed when a GPI-anchor is added. The N-terminal prosegment is cleaved by furin to release a 33 kDa soluble protein that is also known as megakaryocyte potentiating factor (MPF). The membrane bound portion of Mesothelin can also be shed and is detectable in sera. Within the region used as the immunogen, human Mesothelin shares approximately 58% amino acid sequence identity with the mouse or rat protein.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using AF3265	Applications	Species
Denarda Dangaj, Karen L. Abbott, Ananda Mookerjee, Aizhi Zhao, Pamela S. Kirby, Raphael Sandaltzopoulos et al. Mannose Receptor (MR) Engagement by Mesothelin GPI Anchor Polarizes Tumor-Associated Macrophages and Is Blocked by Anti-MR Human Recombinant Antibody PLoS ONE 2011-12-06 [PMID: 22163010]

Array AF3265

• Mesothelin Antibodies
• Mesothelin Lysate
• Mesothelin Protein
• Mesothelin Proteins and Enzymes
• Mesothelin ELISAs