MDL-1/CLEC5A Antibody (226402) [Phycoerythrin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

MDL-1 is an approximately 40 kDa transmembrane glycoprotein belonging to the C-type lectin superfamily (CLEC5A). MDL-1 is expressed on immature myeloid cells, monocytes, macrophages, dendritic cells, neutrophils, NK cells, and osteocytes. It contains a charged lysine in the transmembrane region that enables it to associate with DAP12 and deliver an activating signal. MDL-1 mediates inflammatory responses during autoimmune arthritis and upon binding to Dengue and Japanese encephalitis viruses. The extracellular domain (ECD) of MDL-1 contains a juxtamembrane stalk region and one C-type lectin domain. Within the ECD, mouse and human MDL-1 share 67% amino acid sequence identity. In mouse, alternative splicing generates a short isoform with a 25 aa deletion in the stalk region.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 3 of 3.

Publications using FAB1639P	Applications	Species
Vivekananda Kedage, Diego Ellerman, Mingjian Fei, Wei-Ching Liang, Gu Zhang, Eric Cheng et al. CLEC5a-directed bispecific antibody for effective cellular phagocytosis mAbs 2022-12-31 [PMID: 35293277]
Rapolas Zilionis, Camilla Engblom, Christina Pfirschke, Virginia Savova, David Zemmour, Hatice D. Saatcioglu et al. Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species Immunity 2019-05-01 [PMID: 30979687]
Camilla Engblom, Christina Pfirschke, Rapolas Zilionis, Janaina da Silva Da Silva Martins, Stijn A. Bos, Gabriel Courties et al. Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF high neutrophils Science 2017-12-01 [PMID: 29191879]

Array FAB1639P

• MDL-1/CLEC5A Antibodies
• MDL-1/CLEC5A Lysate
• MDL-1/CLEC5A Protein
• MDL-1/CLEC5A Proteins and Enzymes