MCM7 Antibody

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 5 of 5.

Publications using NB100-252	Applications	Species
Zhu Y, Hu S, Pan X et al. Hepatocyte Sirtuin 6 Protects against Atherosclerosis and Steatohepatitis by Regulating Lipid Homeostasis Cells 2023-08-05 [PMID: 37566087]
Zhou HZ, Zeng HQ, Yuan D et al. NQO1 potentiates apoptosis evasion and upregulates XIAP via inhibiting proteasome-mediated degradation SIRT6 in hepatocellular carcinoma Cell Commun. Signal 2019-12-16 [PMID: 31842909]
Tran L, Schulkin J, Ligon Co et al. Epigenetic modulation of chronic anxiety and pain by histone deacetylation. Mol. Psychiatry. 2014-10-07 [PMID: 25288139]
Gurvich N, Perna F, Farina A et al. L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability. Proc Natl Acad Sci U S A 2010-12-01 [PMID: 21149733]
Nash K, Chen W, Muzyczka N et al. Complete in vitro reconstitution of adeno-associated virus DNA replication requires the minichromosome maintenance complex proteins. J Virol 2008-02-01 [PMID: 18057257]

Array NB100-252

• MCM7 Antibodies
• MCM7 Lysate
• MCM7 Proteins