Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Antibody

JARID1B (Jumonji AT-rich interactive domain 1B) is a member of the JARID 1 family of proteins that catalyze the demethylation of histones on lysine. The Jarid 1 family members include JARID1A, JARID1B, JARID1C and JARID1D. The members of this family possess a Jumonji C (JmjC) and Jumonji N (JmjN) domain as well as one ARID (AT-rich interactive domain) and three PHD-type zinc fingers. As histone demethylases, JARID 1 proteins function as transcriptional repressors. JARID1B expression is largely restricted to testis and may play a critical role in tumorigenesis as it has been found to be upregulated in prostate and breast cancer. Alternative names for JARID1B include retinoblastoma-binding protein 2 homolog 1, RBP2-H1, cancer/testis antigen 31, CT31, PLU-1, PUT1, and KDM5B.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: B/N, Chemotaxis, IF/IHC, IP, WB.

Showing Publications 1 - 10 of 10.

Publications using NBP1-84352	Applications	Species
Zhang SM, Cai WL, Liu X Et al. KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements Nature 2021-10-01 [PMID: 34671158] (Chemotaxis)	Chemotaxis
Li G, Kanagasabai T, Lu W et al. KDM5B Is Essential for the Hyperactivation of PI3K/AKT Signaling in Prostate Tumorigenesis Cancer Research 2020-11-01 [PMID: 32868382] (B/N, WB)	B/N, WB
Wang L, Mao Y, Du G et al. Overexpression of JARID1B is associated with poor prognosis and chemotherapy resistance in epithelial ovarian cancer. Tumour Biol 2015-04-01 [PMID: 25663457] (IF/IHC, Human)	IF/IHC	Human
Lu W, Liu S, Li B et al. SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination. Oncotarget 2015-01-20 [PMID: 25596733] (WB)	WB
Nishibuchi G, Shibata Y, Hayakawa T et al. Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex. J Biol Chem 2014-09-04 [PMID: 25190814] (IP, WB, Human)	IP, WB	Human
Yamamoto S, Wu Z, Russnes HG et al. JARID1B is a luminal lineage-driving oncogene in breast cancer. Cancer Cell 2014-06-16 [PMID: 24937458] (IP, IF/IHC, Human)	IP, IF/IHC	Human
Zou MR, Cao J, Liu Z et al. Histone Demethylase Jumonji AT-rich Interactive Domain 1B (JARID1B) Controls Mammary Gland Development by Regulating Key Developmental and Lineage Specification Genes. J Biol Chem 2014-06-20 [PMID: 24802759] (WB, Mouse)	WB	Mouse
Klein BJ, Piao L, Xi Y et al. The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers. Cell Rep 2014-01-30 [PMID: 24412361]
Wouters J, Stas M, Gremeaux L et al. The Human Melanoma Side Population Displays Molecular and Functional Characteristics of Enriched Chemoresistance and Tumorigenesis. PLoS One 2013-01-01 [PMID: 24098529]
Hayami S, Yoshimatsu M, Veerakumarasivam A et al. Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Mol Cancer. 2010-05-13 [PMID: 20226085]

Array NBP1-84352

• Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Antibodies
• Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Lysate
• Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Proteins