LHX5 Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

LHX5 (LIM/homeobox protein 5) is a member of the LIM homeobox gene family. It is expressed in embryonic CNS, and appears to contribute to the formation and maintenance of multiple neuronal phenotypes. In the cerebellum, LHX5 promotes Purkinje cell development; in the spinal cord, LHX5 maintains a GABAergic phenotype in select dorsal horn interneurons. LHX5 is reported to act as a Wnt pathway antagonist through its stimulation of sFRP-1 and -5 secretion. Human LHX5 is 402 amino acids (aa) in length. It contains two LIM Zn-binding domains (aa 3-61 and 62-125), one phosphorylation site at Tyr119, and a DNA-binding homeodomain (aa 180‑239). Over aa 265-402, human LHX5 shares 97% aa identity with mouse LHX5, and 60% aa identity with its paralogue (common ancestoral) gene, LHX1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: IHC, Western Blot.

Showing Publications 1 - 5 of 5.

Publications using AF6290	Applications	Species
Takata, N;Miska, JM;Morgan, MA;Patel, P;Billingham, LK;Joshi, N;Schipma, MJ;Dumar, ZJ;Joshi, NR;Misharin, AV;Embry, RB;Fiore, L;Gao, P;Diebold, LP;McElroy, GS;Shilatifard, A;Chandel, NS;Oliver, G; Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis Nature communications 2023-07-14 [PMID: 37452018] (IHC, Mouse)	IHC	Mouse
Ugomma C. Eze, Aparna Bhaduri, Maximilian Haeussler, Tomasz J. Nowakowski, Arnold R. Kriegstein Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia Nature Neuroscience 2021-04-01 [PMID: 33723434]
S Cruz-Molin, P Respuela, C Tebartz, P Kolovos, M Nikolic, R Fueyo, WF van Ijcken, F Grosveld, P Frommolt, H Bazzi, A Rada-Igles PRC2 Facilitates the Regulatory Topology Required for Poised Enhancer Function during Pluripotent Stem Cell Differentiation Cell Stem Cell, 2017-03-09;0(0):. 2017-03-09 [PMID: 28285903] (Western Blot, Mouse)	Western Blot	Mouse
Junge HJ, Yung AR, Goodrich LV, Chen Z. Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord. Neural Dev. 10/26/2016 [PMID: 27784329]
Leggere JC, Saito Y, Darnell RB et al. NOVA regulate Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord. Elife. 5/25/2016 [PMID: 27223328]

Array AF6290

• LHX5 Antibodies
• LHX5 Protein