Leukotriene B4 R1 Antibody (203/14F11) [Phycoerythrin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Polymorphonuclear granulocytes secrete the lipid chemotactic mediator Leukotriene B4 (LTB4) in response to inflammatory stimuli (1). Neutrophils, monocytes and lymphocytes respond to LTB4 via specific receptors localized on the cell surface (2-4). The high affinity LTB4 Receptor known as BLT1 is only expressed on leukocytes (5-7) while a second low affinity receptor BLT2 is expressed more ubiquitously (8, 9). The BLT1 and BLT2 are G-protein linked seven-transmembrane spanning receptors that share about 37-45% amino acid identity (8, 9). Enhanced LTB4 production and engagement of the BLT receptors can be important in allergic and inflammatory diseases such as asthma (10), allergic encephalomyelitis (11), endotoxic shock (12), ischemia (12), psoriasis (13), rheumatoid arthritis (14) and inflammatory bowel disease (15). In addition, it has been reported that BLT1 can function as an additional co-receptor for HIV infection of CD4⁺ T cells (16, 17). Investigations into the mechanisms and potential inhibitors of LTB4 binding to its’ receptors may provide insight into possible treatment modalities for a number of inflammatory disorders.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 3 of 3.

Publications using FAB099P	Applications	Species
F Sasaki, T Koga, M Ohba, K Saeki, T Okuno, K Ishikawa, T Nakama, S Nakao, S Yoshida, T Ishibashi, H Ahmadieh, MR Kanavi, A Hafezi-Mog, JM Penninger, KH Sonoda, T Yokomizo Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models JCI Insight, 2018-09-20;3(18):. 2018-09-20 [PMID: 30232269] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Sveinbjornsson B, Rasmuson A, Baryawno N, Wan M, Pettersen I, Ponthan F, Orrego A, Haeggstrom JZ, Johnsen JI, Kogner P Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy. FASEB J., 2008-06-30;22(10):3525-36. 2008-06-30 [PMID: 18591367] (Flow Cytometry, Human)	Flow Cytometry	Human
Sabirsh A, Bywater RP, Bristulf J, Owman C, Haeggstrom JZ Residues from transmembrane helices 3 and 5 participate in leukotriene B4 binding to BLT1. Biochemistry, 2006-05-09;45(18):5733-44. 2006-05-09 [PMID: 16669617] (Flow Cytometry, Human)	Flow Cytometry	Human

Array FAB099P

• Leukotriene B4 R1 Antibodies
• Leukotriene B4 R1 Lysates
• Leukotriene B4 R1 Protein