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Kv7.4 Antibody (S43/6) [DyLight 350]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications ICC/IF, IHC, IP, MA
Clone
S43/6
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 350

Kv7.4 Antibody (S43/6) [DyLight 350] Summary

Description
This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Immunogen
Fusion protein amino acids 2-77 of human KCNQ4
Localization
Plasma Membrane , Basal Cell Membrane
Specificity
Detects approx 77kDa.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
KCNQ4
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunoprecipitation
  • Microarray

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Kv7.4 Antibody (S43/6) [DyLight 350]

  • DFNA2
  • DFNA2A
  • KCNQ4
  • KQT-like 4
  • Kv7.4
  • potassium channel KQT-like 4
  • Potassium channel subunit alpha KvLQT4
  • potassium voltage-gated channel subfamily KQT member 4
  • potassium voltage-gated channel, KQT-like subfamily, member 4
  • Voltage-gated potassium channel subunit Kv7.4

Background

KCNQ4 is encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Additional Kv7.4 Products

Array NBP2-12899UV

Research Areas for Kv7.4 Antibody (NBP2-12899UV)

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Bioinformatics

Gene Symbol KCNQ4