ITPR2 Antibody

Inositol 1,4,5-triphosphate (IP3) receptors are a form of ligand-gated ion channels that are activated by cytosolic Ca2+ and IP3. They are localized to intracellular membranes, such as the endoplasmic reticulum, and mediate the mobilization of intracellular Ca2+ stores. IP3 receptors play an important role in intracellular Ca2+ signaling in a variety of cell types. There are three IP3 receptor subtypes; IP3R1, IP3R2 and IP3R3, which exist as homo- and heterotetramers. All subtypes are closely associated with calmodulin and FK506-binding protein and are modulated through phosphorylation by PKA, PKC, PKG and CaMKII.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 7 of 7.

Publications using NB100-2466	Applications	Species
Olivares-Florez S, Czolbe M, Riediger F et al. Nuclear calcineurin is a sensor for detecting Ca2+ release from the nuclear envelope via IP3R. J. Mol. Med. 2018-11-01 [PMID: 30293136] (ICC/IF, Mouse)	ICC/IF	Mouse
Liu F, Li Zf, Wang Zy, Wang L. Role of subcellular calcium redistribution in regulating apoptosis and autophagy in cadmium-exposed primary rat proximal tubular cells. J. Inorg. Biochem. 2016-09-14 [PMID: 27665314] (WB)	WB
Wang H, Wang ZK, Jiao P et al. Redistribution of subcellular calcium and its effect on apoptosis in primary cultures of rat proximal tubular cells exposed to lead Toxicology 2015-04-25 [PMID: 25921245] (WB, Rat)	WB	Rat
Ljubojevic S, Radulovic S, Leitinger G et al. Early Remodelling of Perinuclear Ca2+ Stores and Nucleoplasmic Ca2+ Signalling During the Development of Hypertrophy and Heart Failure. Circulation. 2014-06-13 [PMID: 24928680] (ICC/IF, WB, Mouse, Human) Details: In this study involving hypertrophy and heart failure models, goat polyclonal anti-IP3R2 antibody from Novus Biologicals (ITPR2 antibody, NB100-2466) was used for ICC-IF immunostaining of Human and Mouse cardiomyocytes isolated from nonfailing and failing hearts (Figure 2 B). Antibody also used for WB in human heart homogenate (Figure S5C) and for immunogold labeling/transmission immuno-electron microscopy in mouse hearts (Figure 2 D).	ICC/IF, WB	Mouse, Human
Harr MW, McColl KS, Zhong F et al. Glucocorticoids downregulate Fyn and inhibit IP(3)-mediated calcium signaling to promote autophagy in T lymphocytes Autophagy 2010-10-01 [PMID: 20814235] (WB, Mouse)	WB	Mouse
Futatsugi A, Nakamura T, Yamada MK et al. IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science 2005-09-30 [PMID: 16195467]
Kaufman AM Non-canonical members of circuits: A role for the locus coeruleus in reward related place field plasticity, and investigating differences in astrocyte calcium signaling between hippocampal layers Thesis 2020-01-01 (ICC/IF, Mouse)	ICC/IF	Mouse

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	WB	Mouse	01/22/2010	View Summary Application Western Blot Sample Tested mouse cell line, Sample Amount: 80ug Species Mouse

Array NB100-2466

• ITPR2 Antibodies
• ITPR2 Proteins