Importin-7 Antibody

Importin-7 (IOP7) belongs to the Importin beta family and contains an importin N-terminal domain. It functions in nuclear protein import in association with importin-beta subunit kPNB1. It mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 and the nuclear import of H2A, H2B, H3 and H4 histones in vitro. Studies suggest it acts as a nuclear import receptor for the Glucocorticoid receptors. It also acts as a receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. Reports indicate that in HIV-1 infection, IOP7 binds and mediates the nuclear import of HIV-1 Rev.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Rat, African Green Monkey.

We have publications tested in 2 applications: In vitro, WB.

Showing Publications 1 - 2 of 2.

Publications using NBP2-27150	Applications	Species
Misheva M, Kaur G, Ngoei KR et al. Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress. Biochim. Biophys. Acta. 2014-02-01 [PMID: 24184208] (In vitro, Rat) Details: Rat hepatoma cells, Fig 1D. The results showed that the Importin-7 pAb inhibited nuclear accumulation of p45 NF-E2 but not JNkalpha 1.	In vitro	Rat
Ni L, Llewellyn R, Kesler CT et al. Androgen induces a switch from cytoplasmic retention to nuclear import of the androgen receptor. Mol Cell Biol 2013-12-01 [PMID: 24100013] (WB, African Green Monkey)	WB	African Green Monkey

Array NBP2-27150

• Importin-7 Antibodies
• Importin-7 Proteins