IgM Heavy Chain Antibody (Cocktail) [DyLight 405]

Heavy chain of human IgM

Cytoplasm, Cell Surface and Secreted

B-Cell Marker

Recognizes a protein of 75kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. This monoclonal antibody is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

IgG1 Kappa/IgG2b Kappa

Monoclonal

Mouse

IGHM

Protein A or G purified

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Optimal dilution of this antibody should be experimentally determined.