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Human Survivin Quantikine ELISA Kit

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

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Human Survivin Quantikine ELISA Kit Summary

Background
The Quantikine Human Survivin immunoassay is a 4.5 hour solid phase ELISA designed to measure human Survivin in cell culture supernates, serum, plasma, and urine. It contains E. coli-expressed recombinant human Survivin and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human Survivin showed linear curves that were parallel to the stan...dard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human Survivin.
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Specificity
Natural and recombinant human Survivin
Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
BIRC5

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DSV00.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Survivin Quantikine ELISA Kit

  • API4
  • apoptosis inhibitor 4
  • Apoptosis inhibitor survivin
  • baculoviral IAP repeat-containing 5
  • Baculoviral IAP Repeat-Containing Protein 5
  • BIRC5
  • EPR-1
  • IAP4
  • survivin variant 3 alpha
  • Survivin

Background

Survivin is a member of the Inhibitor of Apoptosis (IAP) gene family and contains a single BIR domain. Increased survivin expression at the G2/M checkpoint contributes to tissue homeostasis and differentiation during embryonic and fetal development. Increased expression in differentiated adult tissues, however, frequently results in unchecked cell survival, resulting in cancer. Survivin can protect cells from caspase-induced apoptosis activated in mitosis presumably by binding to Caspase-3, -7, and -9.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Survivin (DSV00)(10)

We have publications tested in 1 confirmed species: Human.


Filter By Application
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Filter By Species
Human
(10)
All Species
Showing Publications 1 - 10 of 10.
Publications using DSV00 Applications Species
E Arellano-O, B Romero-Rom, V Sánchez-Ló, J Martín-Jua, F Rodríguez-, R Otero-Cand Survivin is a negative prognostic factor in malignant pleural effusion Eur. J. Clin. Invest., 2018-02-13;0(0):. 2018-02-13 [PMID: 29359509] (Human) Human
S Khan, J Simpson, JC Lynch, D Turay, S Mirshahidi, A Gonda, TW Sanchez, CA Casiano, NR Wall Racial differences in the expression of inhibitors of apoptosis (IAP) proteins in extracellular vesicles (EV) from prostate cancer patients PLoS ONE, 2017-10-05;12(10):e0183122. 2017-10-05 [PMID: 28981528] (Human) Human
A Karowicz-B, U Kowalska-K, D Estemberg, A Sikora-Szu Evaluation of tissue metalloproteinase inhibitor TIMP-1 and Survivin levels during third trimester pregnancy - a preliminary report Ginekol. Pol., 2017-01-01;88(4):198-204. 2017-01-01 [PMID: 28509321] (Human) Human
Immunohistochemical expression and serum level of survivin protein in colorectal cancer patients Oncol Lett, 2016-09-01;12(5):3591-3597. 2016-09-01 [PMID: 27900041] (Human) Human
Dellal , Fatma Di, Niyazoglu , Mutlu, Gorar , Suheyla, Ademoglu , Esranur, Candan , Zehra, Bekdemir , Handan, Hacioglu , Yalcin, Kaya , Fatih On Serum survivin increases in prolactinoma. J Clin Med Res, 2015-02-09;7(4):248-52. 2015-02-09 [PMID: 25699121] (Human) Human
Dobrzycka B, Mackowiak-Matejczyk B, Terlikowska K, Kulesza-Bronczyk B, Kinalski M, Terlikowski S Prognostic significance of pretreatment VEGF, survivin, and Smac/DIABLO serum levels in patients with serous ovarian carcinoma. Tumour Biol, 2015-01-12;0(0):4157. 2015-01-12 [PMID: 25577253] (Human) Human
Ren , Y-Q, Zhang , H-Y, Su , T, Wang , X-H, Zhang , L Clinical significance of serum survivin in patients with pancreatic ductal adenocarcinoma. Eur Rev Med Pharmacol Sci, 2014-10-01;18(20):3063-8. 2014-10-01 [PMID: 25392106] (Human) Human
Khan S, Bennit H, Turay D, Perez M, Mirshahidi S, Yuan Y, Wall N Early diagnostic value of survivin and its alternative splice variants in breast cancer. BMC Cancer, 2014-03-12;14(0):176. 2014-03-12 [PMID: 24620748] (Human) Human
Khan , Salma, Jutzy , Jessica, Valenzuela , Malyn Ma, Turay , David, Aspe , Jonathan, Ashok , Arjun, Mirshahidi , Saied, Mercola , Dan, Lilly , Michael, Wall , Nathan R Plasma-derived exosomal survivin, a plausible biomarker for early detection of prostate cancer. PLoS ONE, 2012-10-16;7(10):e46737. 2012-10-16 [PMID: 23091600] (Human) Human
Khan S, Aspe JR, Asumen MG, Almaguel F, Odumosu O, Acevedo-Martinez S, De Leon M, Langridge WH, Wall NR Extracellular, cell-permeable survivin inhibits apoptosis while promoting proliferative and metastatic potential. Br. J. Cancer, 2009-03-17;100(7):1073-86. 2009-03-17 [PMID: 19293795] (Human) Human

Reviews for Survivin (DSV00) (0)

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for Survivin (DSV00). (Showing 1 - 1 of 1 FAQs).

  1. Can I use this antibody with species other than those listed?
    • The species we have listed are validated and therefore have a 100% guarantee to work with this antibody. We cannot guarantee that this will work with other species.

Additional Survivin Products

Blogs on Survivin. Showing 1-10 of 16 blog posts - Show all blog posts.


  Read full blog post.

The Ins and Outs of Survivin
By Rachel M.A. Linger, Ph.D.What is survivin?Survivin is a small (16.5 kDa) protein normally found in human fetal tissue. In contrast, survivin is typically undetectable in most normal adult tissues. Expression of ...  Read full blog post.

Survivin - an inhibitor of apoptosis that drives tumorigenesis and metastasis
Apoptosis is the tightly regulated process of programmed cell death. It plays an important role in normal physiologic development but has also been implicated in a number of diseases. Apoptosis is constantly downregulated by a family of anti-apop...  Read full blog post.

Survivin - an inhibitor of apoptosis protein
Survivin is an anti-apoptotic protein which is the smallest protein within a large family of proteins including X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, NAIP, and Livin. Survivin is responsible for a wide range of basic cellula...  Read full blog post.

Cytochrome C - a mediator of apoptosis
Cytochrome C is a small heme protein within the inner mitochondrial membrane responsible for carrying electrons within the respiratory transport chain.  Additionally, cytochrome c has also been identified as a player in programmed cell death (apop...  Read full blog post.

PCNA (Proliferating cell nuclear antigen, polymerase delta auxiliary protein)
PCNA is a nuclear protein essential for DNA replication as well as DNA excision and mismatch repair pathways. It coordinates the recruitment and association of needed components during both of these processes, both of which are essential for cell cycl...  Read full blog post.

Survivin is thrivin'
The survivin anti-apoptotic protein is the smallest member of a large family of proteins such as X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates basic physiological events such as the cell cycle, tumor...  Read full blog post.

Livin: On a Prayer
Livin is a member of the inhibitor of apoptosis proteins (IAP) family that regulates programmed cell death. The Livin protein contains a single baculovirus IAP repeat (BIR) essential for function, along with a COOH-terminal RING-type zinc finger domai...  Read full blog post.

Survivin: As long as I know how to live I know I will
Survivin is an anti-apoptotic protein from a large family with related members such as X-linked IAP, cIAP1 and cIAP2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates fundamental physiological events including the cell cycle, feta...  Read full blog post.

Survivin: Infographic
Survivin is involved in promoting cell proliferation and is an inhibitor of apoptosis. Survivin has a critical role in cancer proliferation and neural development. It may have an impact on neural cell proliferative responses following brain injury.L...  Read full blog post.

Showing 1-10 of 16 blog posts - Show all blog posts.
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Bioinformatics

Gene Symbol BIRC5